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Usefulness of Prostate-Specific Antigen Density as an Indicator for Recommending Prebiopsy Magnetic Resonance Imaging to Prevent Missed Prostate Cancer Diagnoses
DC Field | Value | Language |
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dc.contributor.author | 구교철 | - |
dc.contributor.author | 이광석 | - |
dc.contributor.author | 정병하 | - |
dc.contributor.author | 전진형 | - |
dc.date.accessioned | 2021-12-28T17:35:59Z | - |
dc.date.available | 2021-12-28T17:35:59Z | - |
dc.date.issued | 2021-08 | - |
dc.identifier.issn | 2234-4977 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187176 | - |
dc.description.abstract | Purpose: To identify the indication for recommending prebiopsy magnetic resonance imaging (MRI) to prevent prostate cancer missed diagnoses in cases without prebiopsy MRI. Materials and Methods: Between January 2017 and September 2020, 585 patients suspected with prostate cancer underwent prostate biopsy after MRI. For patients with visible lesions, MRI targeted biopsy using an image-based fusion program was performed in addition to the 12- core systematic biopsy. Patients for whom MRI was performed in other institutions (n=4) and patients who underwent target biopsy alone (n=7) were excluded. Results: Of 574 patients (median prostate-specific antigen [PSA] level, 6.88 ng/mL; mean age, 68.2 years), 342 (59.6%) were diagnosed with prostate cancer (visible lesions=312/449 [69.5%]; nonvisible lesions=30/123 [24.0%]). The detection rates of visible lesions stratified using the Prostate Imaging Reporting and Data System score (3 vs. 4 vs. 5) were 30.9% (54 of 175), 61.2% (150 of 245), and 90.1% (127 of 141), respectively. Multivariate analysis showed that PSA density was a significant factor for presence of visible lesions, prostate cancer, and significant prostate cancer diagnosis. Among patients with positive lesions, 27 (8.2%) were diagnosed with prostate cancer concomitant with negative systematic biopsy results. A PSA density of 0.15 ng/mL/cm3 was identified as the significant cutoff value for predicting positive target biopsy in groups with negative systematic biopsy. Sixty of the negative target lesions (26.1%) were diagnosed using systematic biopsy. Conclusions: To maximize cancer detection rates, both targeted and systematic biopsies should be implemented. PSA density was identified as a useful factor for recommending prebi opsy MRI to patients suspected with prostate cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | Korean Journal of Urological Oncology | - |
dc.publisher | Korean Journal of Urological Oncology | - |
dc.relation.isPartOf | Korean Journal of Urological Oncology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Usefulness of Prostate-Specific Antigen Density as an Indicator for Recommending Prebiopsy Magnetic Resonance Imaging to Prevent Missed Prostate Cancer Diagnoses | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨의학교실) | - |
dc.contributor.googleauthor | Jin Hyung Jeon | - |
dc.contributor.googleauthor | Kyo Chul Koo | - |
dc.contributor.googleauthor | Byung Ha Chung | - |
dc.contributor.googleauthor | Kwang Suk Lee | - |
dc.identifier.doi | 10.22465/kjuo.2021.19.3.155 | - |
dc.contributor.localId | A00188 | - |
dc.contributor.localId | A02668 | - |
dc.contributor.localId | A03607 | - |
dc.relation.journalcode | J02133 | - |
dc.identifier.eissn | 2233-5633 | - |
dc.subject.keyword | Magnetic resonance imaging | - |
dc.subject.keyword | Prostate cancer | - |
dc.subject.keyword | Prostate-specific antigen | - |
dc.contributor.alternativeName | Koo, Kyo Chul | - |
dc.contributor.affiliatedAuthor | 구교철 | - |
dc.contributor.affiliatedAuthor | 이광석 | - |
dc.contributor.affiliatedAuthor | 정병하 | - |
dc.citation.volume | 19 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 155 | - |
dc.citation.endPage | 163 | - |
dc.identifier.bibliographicCitation | Korean Journal of Urological Oncology, Vol.19(3) : 155-163, 2021-08 | - |
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