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Efficacy and Safety of a Standardized Soy and Hop Extract on Menopausal Symptoms: A 12-Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trial
DC Field | Value | Language |
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dc.contributor.author | 김혜인 | - |
dc.contributor.author | 서석교 | - |
dc.contributor.author | 이인하 | - |
dc.date.accessioned | 2021-12-28T17:34:18Z | - |
dc.date.available | 2021-12-28T17:34:18Z | - |
dc.date.issued | 2021-11 | - |
dc.identifier.issn | 1075-5535 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187163 | - |
dc.description.abstract | Objectives: Soy and hop extracts have been investigated as alternatives for hormone replacement therapy. However, their combined efficacy is not known. We investigated the efficacy and safety of a combined soy and hop extract on postmenopausal symptoms. Design: Double-blinded, randomized controlled trial. Settings/Location: Gynecological outpatient clinic of tertiary hospital. Subjects: Seventy-eight women with moderate or severe menopausal symptoms assessed as modified Kupperman Menopoausal Index (KMI) scores >20. Interventions: They received either a combined soy and hop extract (n = 38) or placebo (n = 40). Outcome measures: Menopausal symptoms were evaluated through self-reporting of modified Kupperman Menopausal Index (KMI) scores at baseline and after 6 and 12 weeks. We assessed serum levels of bone metabolism biomarkers, ultrasonographic parameters, hormone profiles, compliance, and safety. Results: After 12 weeks of the treatment, treatment group scores decreased by 20.61 points compared with 14.80 points in the placebo group (p < 0.05). Fatigue, paresthesia, arthralgia, and myalgia, palpitation and vaginal dryness significantly improved more in the treatment group compared with the placebo group after 12 weeks (p < 0.05). Urine N-telopeptide in participants ≥50 years in the treatment group showed a reduced increase. Endometrial thickness and hormonal profiles did not show significant changes in either group. No serious adverse events were reported. Conclusion: The results suggest that 190 mg of combined soy and hop extract is safe and effective for improvement of menopausal symptoms. CRIS No.: KCT0006019. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Mary Ann Liebert, Inc. | - |
dc.relation.isPartOf | JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Double-Blind Method | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hot Flashes* / drug therapy | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Humulus | - |
dc.subject.MESH | Isoflavones* / therapeutic use | - |
dc.subject.MESH | Menopause | - |
dc.subject.MESH | Phytotherapy* | - |
dc.subject.MESH | Plant Extracts* / therapeutic use | - |
dc.subject.MESH | Soybeans | - |
dc.title | Efficacy and Safety of a Standardized Soy and Hop Extract on Menopausal Symptoms: A 12-Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trial | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics and Gynecology (산부인과학교실) | - |
dc.contributor.googleauthor | Hye In Kim | - |
dc.contributor.googleauthor | Min Kyoung Kim | - |
dc.contributor.googleauthor | Inha Lee | - |
dc.contributor.googleauthor | Jisun Yun | - |
dc.contributor.googleauthor | Eui Hyeok Kim | - |
dc.contributor.googleauthor | Seok Kyo Seo | - |
dc.identifier.doi | 10.1089/acm.2021.0027 | - |
dc.contributor.localId | A05969 | - |
dc.contributor.localId | A01888 | - |
dc.contributor.localId | A05497 | - |
dc.relation.journalcode | J01229 | - |
dc.identifier.eissn | 1557-7708 | - |
dc.identifier.pmid | 34399063 | - |
dc.identifier.url | https://www.liebertpub.com/doi/10.1089/acm.2021.0027 | - |
dc.subject.keyword | hop | - |
dc.subject.keyword | hot flush | - |
dc.subject.keyword | isoflavones | - |
dc.subject.keyword | menopause | - |
dc.subject.keyword | soy | - |
dc.contributor.alternativeName | Kim, Hye In | - |
dc.contributor.affiliatedAuthor | 김혜인 | - |
dc.contributor.affiliatedAuthor | 서석교 | - |
dc.contributor.affiliatedAuthor | 이인하 | - |
dc.citation.volume | 27 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 959 | - |
dc.citation.endPage | 967 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE, Vol.27(11) : 959-967, 2021-11 | - |
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