0 187

Cited 0 times in

Efficacy and Safety of a Standardized Soy and Hop Extract on Menopausal Symptoms: A 12-Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trial

DC Field Value Language
dc.contributor.author김혜인-
dc.contributor.author서석교-
dc.contributor.author이인하-
dc.date.accessioned2021-12-28T17:34:18Z-
dc.date.available2021-12-28T17:34:18Z-
dc.date.issued2021-11-
dc.identifier.issn1075-5535-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/187163-
dc.description.abstractObjectives: Soy and hop extracts have been investigated as alternatives for hormone replacement therapy. However, their combined efficacy is not known. We investigated the efficacy and safety of a combined soy and hop extract on postmenopausal symptoms. Design: Double-blinded, randomized controlled trial. Settings/Location: Gynecological outpatient clinic of tertiary hospital. Subjects: Seventy-eight women with moderate or severe menopausal symptoms assessed as modified Kupperman Menopoausal Index (KMI) scores >20. Interventions: They received either a combined soy and hop extract (n = 38) or placebo (n = 40). Outcome measures: Menopausal symptoms were evaluated through self-reporting of modified Kupperman Menopausal Index (KMI) scores at baseline and after 6 and 12 weeks. We assessed serum levels of bone metabolism biomarkers, ultrasonographic parameters, hormone profiles, compliance, and safety. Results: After 12 weeks of the treatment, treatment group scores decreased by 20.61 points compared with 14.80 points in the placebo group (p < 0.05). Fatigue, paresthesia, arthralgia, and myalgia, palpitation and vaginal dryness significantly improved more in the treatment group compared with the placebo group after 12 weeks (p < 0.05). Urine N-telopeptide in participants ≥50 years in the treatment group showed a reduced increase. Endometrial thickness and hormonal profiles did not show significant changes in either group. No serious adverse events were reported. Conclusion: The results suggest that 190 mg of combined soy and hop extract is safe and effective for improvement of menopausal symptoms. CRIS No.: KCT0006019.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherMary Ann Liebert, Inc.-
dc.relation.isPartOfJOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHDouble-Blind Method-
dc.subject.MESHFemale-
dc.subject.MESHHot Flashes* / drug therapy-
dc.subject.MESHHumans-
dc.subject.MESHHumulus-
dc.subject.MESHIsoflavones* / therapeutic use-
dc.subject.MESHMenopause-
dc.subject.MESHPhytotherapy*-
dc.subject.MESHPlant Extracts* / therapeutic use-
dc.subject.MESHSoybeans-
dc.titleEfficacy and Safety of a Standardized Soy and Hop Extract on Menopausal Symptoms: A 12-Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trial-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Obstetrics and Gynecology (산부인과학교실)-
dc.contributor.googleauthorHye In Kim-
dc.contributor.googleauthorMin Kyoung Kim-
dc.contributor.googleauthorInha Lee-
dc.contributor.googleauthorJisun Yun-
dc.contributor.googleauthorEui Hyeok Kim-
dc.contributor.googleauthorSeok Kyo Seo-
dc.identifier.doi10.1089/acm.2021.0027-
dc.contributor.localIdA05969-
dc.contributor.localIdA01888-
dc.contributor.localIdA05497-
dc.relation.journalcodeJ01229-
dc.identifier.eissn1557-7708-
dc.identifier.pmid34399063-
dc.identifier.urlhttps://www.liebertpub.com/doi/10.1089/acm.2021.0027-
dc.subject.keywordhop-
dc.subject.keywordhot flush-
dc.subject.keywordisoflavones-
dc.subject.keywordmenopause-
dc.subject.keywordsoy-
dc.contributor.alternativeNameKim, Hye In-
dc.contributor.affiliatedAuthor김혜인-
dc.contributor.affiliatedAuthor서석교-
dc.contributor.affiliatedAuthor이인하-
dc.citation.volume27-
dc.citation.number11-
dc.citation.startPage959-
dc.citation.endPage967-
dc.identifier.bibliographicCitationJOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE, Vol.27(11) : 959-967, 2021-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.