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Outcomes of Subtotal Parathyroidectomy Versus Total Parathyroidectomy With Autotransplantation for Tertiary Hyperparathyroidism: Multi-institutional Study

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dc.contributor.author정웅윤-
dc.contributor.author정종주-
dc.date.accessioned2021-12-28T17:32:46Z-
dc.date.available2021-12-28T17:32:46Z-
dc.date.issued2021-10-
dc.identifier.issn0003-4932-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/187153-
dc.description.abstractObjectives: Due to the paucity of data and controversy regarding the preferred surgical approach for managing tertiary HPT, we sought to investigate the outcomes of different surgical approaches in managing this challenging disease. Methods: We performed a multi-center retrospective study to include patients with tertiary HPT who underwent STPX or total parathyroidectomy with autotransplantation (TPX-A). Results: One hundred five patients had kidney transplant, and 43 were on dialysis. In the kidney transplant group, 61 patients underwent STPX, and 44 for TPX-A. Patients' demographics were not significantly different (48.61 ± 9.31 vs 47.95 ± 12.73 years, P = 0.759. The postoperative follow-up showed that the TPX-A cohort had a higher rate of hypoparathyroidism (N = 20, 45.45%) versus (N = 14, 22.95%) with the STPX cohort (P = 0.013). The cure among the TPX-A cohorts (84.09%) over the STPX cohort (73.77%) (P = 0.153). The long-term follow-up showed that the rate of developing temporary (N = 16, 41.03%) or permanent (N = 8, 20.51%) hypoparathyroidism was significantly higher among patients who underwent TPX-A over the patients who underwent STPX (N = 7, 17.95%), and (N = 4, 10.26%), respectively (P = 0.012). There was no statistical difference between the persistence (N = 3, 7.69%) or the recurrence (N = 2, 5.13%) of the HPT in the TPX-A cohort and the STPX cohort (N = 2, 5.13%). (N = 4, 10.26%), respectively, P = 0.644. Conclusions: To our knowledge, this is the largest multi-center study that compared different approaches for managing tertiary HPT. Showing that STPX is the better modality in patients diagnosed with tertiary HPT and had kidney transplants avoiding the risk of hypoparathyroidism.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfANNALS OF SURGERY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHyperparathyroidism / complications-
dc.subject.MESHHyperparathyroidism / surgery*-
dc.subject.MESHHypoparathyroidism / prevention & control-
dc.subject.MESHKidney Transplantation-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHParathyroidectomy*-
dc.subject.MESHRenal Dialysis-
dc.subject.MESHRenal Insufficiency / complications-
dc.subject.MESHRenal Insufficiency / therapy-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTransplantation, Autologous-
dc.titleOutcomes of Subtotal Parathyroidectomy Versus Total Parathyroidectomy With Autotransplantation for Tertiary Hyperparathyroidism: Multi-institutional Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorHye Ryeon Choi-
dc.contributor.googleauthorMohamed A Aboueisha-
dc.contributor.googleauthorAbdallah S Attia-
dc.contributor.googleauthorMahmoud Omar-
dc.contributor.googleauthorAhmad ELnahla-
dc.contributor.googleauthorEman A Toraih-
dc.contributor.googleauthorMohamed Shama-
dc.contributor.googleauthorWoong Youn Chung-
dc.contributor.googleauthorJong Ju Jeong-
dc.contributor.googleauthorEmad Kandil-
dc.identifier.doi10.1097/SLA.0000000000005059-
dc.contributor.localIdA03674-
dc.contributor.localIdA03722-
dc.relation.journalcodeJ00178-
dc.identifier.eissn1528-1140 (-
dc.identifier.pmid34506323-
dc.identifier.urlhttps://journals.lww.com/annalsofsurgery/Fulltext/2021/10000/Outcomes_of_Subtotal_Parathyroidectomy_Versus.17.aspx-
dc.contributor.alternativeNameChung, Woong Youn-
dc.contributor.affiliatedAuthor정웅윤-
dc.contributor.affiliatedAuthor정종주-
dc.citation.volume274-
dc.citation.number4-
dc.citation.startPage674-
dc.citation.endPage679-
dc.identifier.bibliographicCitationANNALS OF SURGERY, Vol.274(4) : 674-679, 2021-10-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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