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Multiple Porous Synthetic Bone Graft Comprising EngineeredMicro-Channel for Drug Carrier and Bone Regeneration

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dc.contributor.author권재성-
dc.contributor.author김광만-
dc.date.accessioned2021-12-28T17:28:51Z-
dc.date.available2021-12-28T17:28:51Z-
dc.date.issued2021-09-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/187121-
dc.description.abstractDue to high demand but limited supply, there has been an increase in the need to replace autologous bone grafts with alternatives that fulfill osteogenic requirements. In this study, two different types of bone grafts were tested for their drug carrying abilities along with their osteogenic properties. Two different types of alendronate-loaded bone grafts, Bio-Oss (bovine bone graft) and InRoad (biphasic synthetic bone graft) were observed to see how different concentrations of alendronate would affect the sustained release to enhance osteogenesis. In this study, defected ovariectomize-induced osteoporotic rat calvarias were observed for 28 days with three different concentrations of alendronate (0 mg, 1 mg, 5 mg) for both Bio-Oss and InRoad. A higher concentration (5 mg) allowed for a more controlled and sustained release throughout the 28-day comparison to those of lower concentrations (0 mg, 1 mg). When comparing Bio-Oss and InRoad through histology and Micro-CT, InRoad showed higher enhancement in osteogenesis. Through this study, it was observed that alendronate not only brings out robust osteogenesis with InRoad bone grafts, but also enhances bone regeneration in an alendronate-concentration-dependent manner. The combination of higher concentration of alendronate and multiple porous bone graft containing internal micro-channel structure of InRoad resulted in higher osteogenesis with a sustained release of alendronate.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfMATERIALS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleMultiple Porous Synthetic Bone Graft Comprising EngineeredMicro-Channel for Drug Carrier and Bone Regeneration-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실)-
dc.contributor.googleauthorChun-Sik Bae-
dc.contributor.googleauthorSeung-Hyun Kim-
dc.contributor.googleauthorTaeho Ahn-
dc.contributor.googleauthorYeonji Kim-
dc.contributor.googleauthorSe-Eun Kim-
dc.contributor.googleauthorSeong-Soo Kang-
dc.contributor.googleauthorJae-Sung Kwon-
dc.contributor.googleauthorKwang-Mahn Kim-
dc.contributor.googleauthorSahng-Gyoon Kim-
dc.contributor.googleauthorDaniel Oh-
dc.identifier.doi10.3390/ma14185320-
dc.contributor.localIdA00247-
dc.contributor.localIdA00312-
dc.relation.journalcodeJ02182-
dc.identifier.eissn1996-1944-
dc.identifier.pmid34576544-
dc.subject.keywordbone regeneration-
dc.subject.keyworddrug carrier-
dc.subject.keywordmicro-channel-
dc.subject.keywordmultiple pores-
dc.subject.keywordsynthetic bone graft-
dc.contributor.alternativeNameKwon, Jae-Sung-
dc.contributor.affiliatedAuthor권재성-
dc.contributor.affiliatedAuthor김광만-
dc.citation.volume14-
dc.citation.number18-
dc.citation.startPage5320-
dc.identifier.bibliographicCitationMATERIALS, Vol.14(18) : 5320, 2021-09-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers

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