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Role and Function of O-GlcNAcylation in Cancer
DC Field | Value | Language |
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dc.contributor.author | 김혜련 | - |
dc.contributor.author | 표경호 | - |
dc.contributor.author | 이기쁨 | - |
dc.date.accessioned | 2021-12-28T17:28:29Z | - |
dc.date.available | 2021-12-28T17:28:29Z | - |
dc.date.issued | 2021-10 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187119 | - |
dc.description.abstract | Cancer cells are able to reprogram their glucose metabolism and retain energy via glycolysis even under aerobic conditions. They activate the hexosamine biosynthetic pathway (HBP), and the complex interplay of O-linked N-acetylglucosaminylation (O-GlcNAcylation) via deprivation of nutrients or increase in cellular stress results in the proliferation, progression, and metastasis of cancer cells. Notably, cancer is one of the emerging diseases associated with O-GlcNAcylation. In this review, we summarize studies that delineate the role of O-GlcNAcylation in cancer, including its modulation in metastasis, function with receptor tyrosine kinases, and resistance to chemotherapeutic agents, such as cisplatin. In addition, we discuss the function of O-GlcNAcylation in eliciting immune responses associated with immune surveillance in the tumor microenvironment. O-GlcNAcylation is increasingly accepted as one of the key players involved in the activation and differentiation of T cells and macrophages. Finally, we discuss the prognostic role of O-GlcNAcylation and potential therapeutic agents such as O-linked β-N-acetylglucosamine-transferase inhibitors, which may help overcome the resistance mechanism associated with the reprogramming of glucose metabolism. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | CANCERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Role and Function of O-GlcNAcylation in Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Jii Bum Lee | - |
dc.contributor.googleauthor | Kyoung-Ho Pyo | - |
dc.contributor.googleauthor | Hye Ryun Kim | - |
dc.identifier.doi | 10.3390/cancers13215365 | - |
dc.contributor.localId | A01166 | - |
dc.contributor.localId | A04809 | - |
dc.relation.journalcode | J03449 | - |
dc.identifier.eissn | 2072-6694 | - |
dc.identifier.pmid | 34771527 | - |
dc.subject.keyword | O-GlcNAc transferase | - |
dc.subject.keyword | O-GlcNAcase | - |
dc.subject.keyword | O-GlcNAcylation | - |
dc.subject.keyword | cancer | - |
dc.subject.keyword | cellular stress | - |
dc.subject.keyword | immune surveillance | - |
dc.contributor.alternativeName | Kim, Hye Ryun | - |
dc.contributor.affiliatedAuthor | 김혜련 | - |
dc.contributor.affiliatedAuthor | 표경호 | - |
dc.citation.volume | 13 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 5365 | - |
dc.identifier.bibliographicCitation | CANCERS, Vol.13(12) : 5365, 2021-10 | - |
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