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Proof of the triple prerequisite conditions which are essential for carbapenem resistance development in Klebsiella pneumoniae by using radiation-mediated mutagenesis
DC Field | Value | Language |
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dc.contributor.author | 용동은 | - |
dc.date.accessioned | 2021-12-28T17:26:54Z | - |
dc.date.available | 2021-12-28T17:26:54Z | - |
dc.date.issued | 2021-01 | - |
dc.identifier.issn | 0378-1097 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187104 | - |
dc.description.abstract | Evolution of multi-drug resistant bacteria has led to worldwide research to better understand the various resistance mechanisms in these strains. Every year, novel information on carbapenem resistance and its mechanisms is being discovered. In this study, radiation-mediated mutagenesis was used to transform a carbapenem-resistant Klebsiella pneumoniae strain to a carbapenem-susceptible bacterium. Through this process, we proved three conditions of loss of the OmpK35 and the OmpK36 genes and acquisition of blaCMY-10 worked together to produce carbapenem resistance in K. pneumoniae. Loss of only one of the porins did not evoke carbapenem resistance. This is the first report on the essential contribution of these three components of carbapenem resistance in K. pneumoniae. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Oxford University Press | - |
dc.relation.isPartOf | FEMS MICROBIOLOGY LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Anti-Bacterial Agents / pharmacology* | - |
dc.subject.MESH | Bacterial Proteins / genetics | - |
dc.subject.MESH | Bacterial Proteins / metabolism | - |
dc.subject.MESH | Carbapenems / pharmacology* | - |
dc.subject.MESH | Drug Resistance, Bacterial* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Klebsiella Infections / metabolism* | - |
dc.subject.MESH | Klebsiella Infections / microbiology* | - |
dc.subject.MESH | Klebsiella pneumoniae / drug effects | - |
dc.subject.MESH | Klebsiella pneumoniae / genetics* | - |
dc.subject.MESH | Klebsiella pneumoniae / radiation effects* | - |
dc.subject.MESH | Mutagenesis / radiation effects | - |
dc.subject.MESH | Porins / genetics | - |
dc.subject.MESH | Porins / metabolism | - |
dc.subject.MESH | Radiation | - |
dc.subject.MESH | beta-Lactamases / genetics | - |
dc.subject.MESH | beta-Lactamases / metabolism | - |
dc.title | Proof of the triple prerequisite conditions which are essential for carbapenem resistance development in Klebsiella pneumoniae by using radiation-mediated mutagenesis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | Naina Adren Pinto | - |
dc.contributor.googleauthor | Roshan D'Souza | - |
dc.contributor.googleauthor | Le Phuong Nguyen | - |
dc.contributor.googleauthor | Thao Nguyen Vu | - |
dc.contributor.googleauthor | Dongeun Yong | - |
dc.identifier.doi | 10.1093/femsle/fnaa189 | - |
dc.contributor.localId | A02423 | - |
dc.relation.journalcode | J00892 | - |
dc.identifier.eissn | 1574-6968 | - |
dc.identifier.pmid | 33469646 | - |
dc.identifier.url | https://academic.oup.com/femsle/article-abstract/368/1/fnaa189/6104481 | - |
dc.subject.keyword | Klebsiella pneumoniae | - |
dc.subject.keyword | CMY-10 | - |
dc.subject.keyword | carbapenem | - |
dc.subject.keyword | proton particle | - |
dc.subject.keyword | radiation | - |
dc.contributor.alternativeName | Yong, Dong Eun | - |
dc.contributor.affiliatedAuthor | 용동은 | - |
dc.citation.volume | 368 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | fnaa189 | - |
dc.identifier.bibliographicCitation | FEMS MICROBIOLOGY LETTERS, Vol.368(1) : fnaa189, 2021-01 | - |
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