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A collagen-AS/εPLL bilayered artificial substitute regulates anti-inflammation and infection for initial inflamed wound healing

Authors
 Gyeung Mi Seon  ;  Mi Hee Lee  ;  Min-Ah Koo  ;  Seung Hee Hong  ;  Ye Jin Park  ;  Ha Kyeong Jeong  ;  Jong-Chul Park 
Citation
 BIOMATERIALS SCIENCE, Vol.9(20) : 6865-6878, 2021-08 
Journal Title
BIOMATERIALS SCIENCE
ISSN
 2047-4830 
Issue Date
2021-08
MeSH
Anti-Inflammatory Agents / pharmacology ; Collagen ; Lysine* ; Triterpenes ; Wound Healing*
Abstract
Despite the development of advanced tissue engineering substitutes, inflammation is still a significant problem that can arise from inflamed burn injuries, chronic wounds, or microbial diseases. Although topical wound dressing accelerates healing by minimizing or preventing the consequences of skin inflammation, there remains a need for the development of a novel substitute scaffold that can effectively eliminate immoderate inflammation and infection in the initial phase of the healing meachanism. In this study, an artificial skin substitute scaffold fabricated with asiaticoside (AS) and epsilon-poly-L-lysine (εPLL) was prepared. Upon the release of these bioactive compounds, they accelerate wound healing and inhibit any bacterial infection at the wound site. We determined whether AS and εPLL exhibit anti-inflammatory and bactericidal effects through different mechanisms. Collectively, the collagen-AS/εPLL artificial skin substitute could be a significant therapeutic agent for scar-less rapid wound healing (without infection and inflammation) of initially-inflamed full-thickness wounds.
Full Text
https://pubs.rsc.org/en/content/articlelanding/2021/BM/D1BM01071A
DOI
10.1039/d1bm01071a
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Koo, Min-Ah(구민아) ORCID logo https://orcid.org/0000-0002-8671-1131
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
Lee, Mi Hee(이미희) ORCID logo https://orcid.org/0000-0002-9630-7044
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187092
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