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Association of vancomycin trough concentration on the treatment outcome of patients with bacteremia caused by Enterococcus species
DC Field | Value | Language |
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dc.contributor.author | 구남수 | - |
dc.contributor.author | 김무현 | - |
dc.contributor.author | 김정호 | - |
dc.contributor.author | 백예지 | - |
dc.contributor.author | 성혜 | - |
dc.contributor.author | 손유진 | - |
dc.contributor.author | 송영구 | - |
dc.contributor.author | 안진영 | - |
dc.contributor.author | 염준섭 | - |
dc.contributor.author | 이상국 | - |
dc.contributor.author | 임정훈 | - |
dc.contributor.author | 임종백 | - |
dc.contributor.author | 정수진 | - |
dc.contributor.author | 조윤숙 | - |
dc.contributor.author | 최준용 | - |
dc.contributor.author | 현종훈 | - |
dc.date.accessioned | 2021-12-28T17:22:50Z | - |
dc.date.available | 2021-12-28T17:22:50Z | - |
dc.date.issued | 2021-10 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187076 | - |
dc.description.abstract | Background: Pharmacokinetic-pharmacodynamic (PK/PD) targets of vancomycin therapy have been recognized for methicillin-resistant Staphylococcus aureus infections but not for other gram-positive bacterial infections. Therefore, we investigated whether vancomycin concentration targets such as the trough level and ratio of the area under the curve to minimum inhibitory concentration (AUC/MIC) are associated with the treatment outcome in enterococcal bacteremia. Methods: A retrospective cohort analysis enrolled patients with bacteremia caused by vancomycin-susceptible Enterococcus faecium and Enterococcus faecalis who were treated with vancomycin from January 2007 to December 2017 at a tertiary hospital located in Seoul, South Korea. Patients without vancomycin concentrations were excluded from the study. The primary outcome was 28-day all-cause mortality. Results: A total of 37 patients were enrolled-26 with E. faecium infection and 11 with E. faecalis infection. The 28-day all-cause mortality rate was 21.6 %. In univariate analysis, vancomycin trough level (≤ 15 µg/mL; p = 0.042), age (p = 0.044), and septic shock (p = 0.049) were associated with 28-day mortality but not AUC24/MIC (> 389; p = 0.479). In multivariate analysis, vancomycin trough concentration (≤ 15 µg/mL; p = 0.041) and younger age (p = 0.031) were associated with 28-day mortality in patients with enterococcal bacteremia. Conclusions: In this study, a vancomycin trough level of 15 µg/mL or lower was associated with 28-day mortality in enterococcal bacteremia. However, relatively large prospective studies are needed to examine the efficacy of vancomycin PK/PD parameters in patients with enterococcal bacteremia. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | BioMed Central | - |
dc.relation.isPartOf | BMC INFECTIOUS DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Anti-Bacterial Agents / therapeutic use | - |
dc.subject.MESH | Bacteremia* / drug therapy | - |
dc.subject.MESH | Enterococcus | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Methicillin-Resistant Staphylococcus aureus* | - |
dc.subject.MESH | Microbial Sensitivity Tests | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Staphylococcal Infections* / drug therapy | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Vancomycin / therapeutic use | - |
dc.title | Association of vancomycin trough concentration on the treatment outcome of patients with bacteremia caused by Enterococcus species | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Yujin Sohn | - |
dc.contributor.googleauthor | John Hoon Rim | - |
dc.contributor.googleauthor | Yunsuk Cho | - |
dc.contributor.googleauthor | Jonghoon Hyun | - |
dc.contributor.googleauthor | Yaejee Baek | - |
dc.contributor.googleauthor | Moohyun Kim | - |
dc.contributor.googleauthor | Jung Ho Kim | - |
dc.contributor.googleauthor | Hye Seong | - |
dc.contributor.googleauthor | Jin Young Ahn | - |
dc.contributor.googleauthor | Sang-Guk Lee | - |
dc.contributor.googleauthor | Jong-Beack Lim | - |
dc.contributor.googleauthor | Su Jin Jeong | - |
dc.contributor.googleauthor | Nam Su Ku | - |
dc.contributor.googleauthor | Jun Yong Choi | - |
dc.contributor.googleauthor | Joon-Sup Yeom | - |
dc.contributor.googleauthor | Young Goo Song | - |
dc.identifier.doi | 10.1186/s12879-021-06809-x | - |
dc.contributor.localId | A00189 | - |
dc.contributor.localId | A04521 | - |
dc.contributor.localId | A00902 | - |
dc.contributor.localId | A05921 | - |
dc.contributor.localId | A05140 | - |
dc.contributor.localId | A05924 | - |
dc.contributor.localId | A02037 | - |
dc.contributor.localId | A02267 | - |
dc.contributor.localId | A02353 | - |
dc.contributor.localId | A02810 | - |
dc.contributor.localId | A04654 | - |
dc.contributor.localId | A03403 | - |
dc.contributor.localId | A03638 | - |
dc.contributor.localId | A05940 | - |
dc.contributor.localId | A04191 | - |
dc.contributor.localId | A05944 | - |
dc.relation.journalcode | J00360 | - |
dc.identifier.eissn | 1471-2334 | - |
dc.identifier.pmid | 34702193 | - |
dc.subject.keyword | AUC/MIC | - |
dc.subject.keyword | Enterococcus | - |
dc.subject.keyword | Trough level | - |
dc.subject.keyword | Vancomycin | - |
dc.contributor.alternativeName | Ku, Nam Su | - |
dc.contributor.affiliatedAuthor | 구남수 | - |
dc.contributor.affiliatedAuthor | 김무현 | - |
dc.contributor.affiliatedAuthor | 김정호 | - |
dc.contributor.affiliatedAuthor | 백예지 | - |
dc.contributor.affiliatedAuthor | 성혜 | - |
dc.contributor.affiliatedAuthor | 손유진 | - |
dc.contributor.affiliatedAuthor | 송영구 | - |
dc.contributor.affiliatedAuthor | 안진영 | - |
dc.contributor.affiliatedAuthor | 염준섭 | - |
dc.contributor.affiliatedAuthor | 이상국 | - |
dc.contributor.affiliatedAuthor | 임정훈 | - |
dc.contributor.affiliatedAuthor | 임종백 | - |
dc.contributor.affiliatedAuthor | 정수진 | - |
dc.contributor.affiliatedAuthor | 조윤숙 | - |
dc.contributor.affiliatedAuthor | 최준용 | - |
dc.contributor.affiliatedAuthor | 현종훈 | - |
dc.citation.volume | 21 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1099 | - |
dc.identifier.bibliographicCitation | BMC INFECTIOUS DISEASES, Vol.21(1) : 1099, 2021-10 | - |
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