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Implication of metabolic and dopamine transporter PET in dementia with Lewy bodies

Authors
 Sung Woo Kang  ;  Seun Jeon  ;  Young-Gun Lee  ;  Mincheol Park  ;  Kyoungwon Baik  ;  Jin Ho Jung  ;  Seok Jong Chung  ;  Han Soo Yoo  ;  Seong Ho Jeong  ;  Mijin Yun  ;  Phil Hyu Lee  ;  Young H Sohn  ;  Alan C Evans  ;  Byoung Seok Ye 
Citation
 SCIENTIFIC REPORTS, Vol.11(1) : 14394, 2021-12 
Journal Title
SCIENTIFIC REPORTS
Issue Date
2021-12
MeSH
Aged ; Aged, 80 and over ; Cognitive Dysfunction ; Dopamine Plasma Membrane Transport Proteins* ; Humans ; Lewy Body Disease* ; Male ; Middle Aged
Abstract
To evaluate the implication of 18F-fluorodeoxyglucose (FDG)- and dopamine transporter (DAT)-positron emission tomography (PET) in the diagnosis and clinical symptoms of dementia with Lewy bodies (DLB), 55 DLB patients and 49 controls underwent neuropsychological evaluation and FDG-, DAT-, and 18F-Florbetaben (FBB) PET. DAT- and FDG-uptake and FDG/DAT ratio were measured in the anterior and posterior striatum. The first principal component (PC1) of FDG subject residual profiles was identified for each subject. Receiver operating characteristic curve analyses for the diagnosis of DLB were performed using FDG- and DAT-PET biomarkers as predictors, and general linear models for motor severity and cognitive scores were performed adding FBB standardized uptake value ratio as a predictor. Increased metabolism in the bilateral putamen, vermis, and somato-motor cortices, which characterized PC1, was observed in the DLB group, compared to the control group. A combination of posterior putamen FDG/DAT ratio and PC1 showed the highest diagnostic accuracy (91.8% sensitivity and 96.4% specificity), which was significantly greater than that obtained by DAT uptake alone. Striatal DAT uptake and PC1 independently contributed to motor severity and language, memory, frontal/executive, and general cognitive dysfunction in DLB patients, while only PC1 contributed to attention and visuospatial dysfunction.
Files in This Item:
T202104936.pdf Download
DOI
10.1038/s41598-021-93442-y
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Park, Mincheol(박민철)
Baik, Kyoungwon(백경원) ORCID logo https://orcid.org/0000-0001-7215-375X
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Ye, Byoung Seok(예병석) ORCID logo https://orcid.org/0000-0003-0187-8440
Yun, Mi Jin(윤미진) ORCID logo https://orcid.org/0000-0002-1712-163X
Lee, Young-Gun(이영건)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Jeon, Seun(전세운)
Chung, Seok Jong(정석종) ORCID logo https://orcid.org/0000-0001-6086-3199
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/187017
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