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A 10- or 14-day Bismuth-containing Quadruple Therapy as a First-line Helicobacter pylori Eradication Therapy: A Systematic Review and Meta-analysis
DC Field | Value | Language |
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dc.contributor.author | 김지현 | - |
dc.contributor.author | 이용찬 | - |
dc.contributor.author | 임현철 | - |
dc.date.accessioned | 2021-12-28T17:14:33Z | - |
dc.date.available | 2021-12-28T17:14:33Z | - |
dc.date.issued | 2021-03 | - |
dc.identifier.issn | 1738-3331 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/187002 | - |
dc.description.abstract | Background/Aims The eradication rate of the first-line standard triple therapy (STT) for Helicobacter pylori (H. pylori) infection has decreased since 2000; therefore, other first-line therapies are required. This study was aimed at investigating the efficacy of bismuth-containing quadruple therapy (PBMT) for first-line H. pylori eradication compared to STT, sequential therapy (SQT), and concomitant therapy (CT). Materials and Methods The Ovid-MEDLINE, Koreamed, EMBASE, KMBASE, and Cochrane Library databases were searched from January 2008 to July 2018. All identified randomized controlled trials (RCTs) comparing PBMT and non-PBMT for first-line H. pylori eradication therapy were included in the final analysis. Results A total of 3,653 patients from seven RCTs were enrolled. The pooled eradication rates of PBMT by intention-to-treat (ITT) and per-protocol (PP) analyses were 82.1% (95% CI, 68.2~90.8%) and 88.8% (95% CI, 77.1~94.9%), respectively. However, no statistically significant difference was observed in eradication rates of the 10- or 14-day PBMT as compared to 14-day STT, 10-day SQT, and 10-day CT in ITT and PP analyses. PBMT was significantly higher in adverse events than in the other eradication regimens (RR, 1.64; 95% CI, 1.11~2.44). Considerable heterogeneity in adverse events was observed among studies (χ2=88.7; P<0.001, I2=93%). Conclusions PBMT can be the first-line treatment for H. pylori eradication in Korea when other first-line options, including STT, SQT, or CT, are unavailable due to their high adverse event rates. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한 Helicobacter 및 상부위장관 연구학회 | - |
dc.relation.isPartOf | Korean Journal of Helicobacter and Upper Gastrointestinal Research | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | A 10- or 14-day Bismuth-containing Quadruple Therapy as a First-line Helicobacter pylori Eradication Therapy: A Systematic Review and Meta-analysis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Sung Eun Kim | - |
dc.contributor.googleauthor | Hye-Kyung Jung | - |
dc.contributor.googleauthor | Seung Joo Kang | - |
dc.contributor.googleauthor | Yong Chan Lee | - |
dc.contributor.googleauthor | Hyo-Joon Yang | - |
dc.contributor.googleauthor | Seon-Young Park | - |
dc.contributor.googleauthor | Cheol Min Shin | - |
dc.contributor.googleauthor | Hyun Chul Lim | - |
dc.contributor.googleauthor | Jie-Hyun Kim | - |
dc.contributor.googleauthor | Su Youn Nam | - |
dc.contributor.googleauthor | Woon Geon Shin | - |
dc.contributor.googleauthor | Jae Myung Park | - |
dc.contributor.googleauthor | Il Ju Choi | - |
dc.contributor.googleauthor | Jae Gyu Kim | - |
dc.contributor.googleauthor | Miyoung Choi | - |
dc.identifier.doi | 10.7704/kjhugr.2020.0052 | - |
dc.contributor.localId | A00996 | - |
dc.contributor.localId | A02988 | - |
dc.contributor.localId | A03418 | - |
dc.relation.journalcode | J02030 | - |
dc.subject.keyword | Adverse effects | - |
dc.subject.keyword | Bismuth tripotassium dicitrate | - |
dc.subject.keyword | Disease eradication | - |
dc.subject.keyword | Helicobacter pylori | - |
dc.subject.keyword | Meta-analysis | - |
dc.contributor.alternativeName | Kim, Jie-Hyun | - |
dc.contributor.affiliatedAuthor | 김지현 | - |
dc.contributor.affiliatedAuthor | 이용찬 | - |
dc.contributor.affiliatedAuthor | 임현철 | - |
dc.citation.volume | 21 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 48 | - |
dc.citation.endPage | 58 | - |
dc.identifier.bibliographicCitation | Korean Journal of Helicobacter and Upper Gastrointestinal Research, Vol.21(1) : 48-58, 2021-03 | - |
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