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The preventive effect of breastfeeding against ovarian cancer in BRCA1 and BRCA2 mutation carriers: A systematic review and meta-analysis
DC Field | Value | Language |
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dc.contributor.author | 남은지 | - |
dc.contributor.author | 어경진 | - |
dc.date.accessioned | 2021-12-28T17:09:14Z | - |
dc.date.available | 2021-12-28T17:09:14Z | - |
dc.date.issued | 2021-10 | - |
dc.identifier.issn | 0090-8258 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/186961 | - |
dc.description.abstract | Objective: A recent study showed that even a few months of breastfeeding is associated with a significant decrease in the risk of ovarian cancer in the general population. This study aimed to perform a systematic review and meta-analysis to determine the significance of the length of the breastfeeding period on ovarian cancer risk in BRCA1/2 mutation carriers. Methods: PubMed, EMBASE, and Cochrane databases were searched up to June 1, 2021. We included case-control and cohort studies that contained information on breastfeeding and the risk of ovarian cancer in BRCA1/2 mutation carriers. Odds ratios (OR) were meta-analytically pooled using a fixed-effects model.dd RESULTS: Five studies, including one cohort study and four case-control studies, were included in this meta-analysis. Of the 14,601 BRCA1/2 mutation carriers, the overall pooled OR of ever having performed breastfeeding in patients who had ovarian cancer was 0.767 (95% confidence interval [CI], 0.688-0.856) and 0.817 (95% CI, 0.650-1.028) for patients with BRCA1 and BRCA2 mutation, respectively. Breastfeeding for >1 year acted as a protective factor in both BRCA1 [OR: 0.787 (95% CI, 0.682-0.907)] and BRCA2 [OR: 0.567 (95% CI, 0.400-0.802)] mutation carriers. No significant heterogeneity was present (I2 = 0%), and the funnel plot was also properly distributed, showing no publication bias. Conclusions: Breastfeeding is a preventive, modifiable factor for ovarian cancer in BRCA1/2 mutation carriers. Ever having performed breastfeeding was significantly preventive for ovarian cancer in the BRCA1 mutation carriers, however a period of 1 year or more of breastfeeding is required for a reduced ovarian cancer risk in BRCA2 mutation carriers. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Academic Press | - |
dc.relation.isPartOf | GYNECOLOGIC ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | The preventive effect of breastfeeding against ovarian cancer in BRCA1 and BRCA2 mutation carriers: A systematic review and meta-analysis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Obstetrics and Gynecology (산부인과학교실) | - |
dc.contributor.googleauthor | Kyung Jin Eoh | - |
dc.contributor.googleauthor | Eun Young Park | - |
dc.contributor.googleauthor | Yoon Jung Chang | - |
dc.contributor.googleauthor | Hyeong In Ha | - |
dc.contributor.googleauthor | Juhye Hong | - |
dc.contributor.googleauthor | Dan Huang | - |
dc.contributor.googleauthor | Eun Ji Nam | - |
dc.contributor.googleauthor | Myong Cheol Lim | - |
dc.identifier.doi | 10.1016/j.ygyno.2021.07.028 | - |
dc.contributor.localId | A01262 | - |
dc.contributor.localId | A04842 | - |
dc.relation.journalcode | J00956 | - |
dc.identifier.eissn | 1095-6859 | - |
dc.identifier.pmid | 34304906 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0090825821005904 | - |
dc.subject.keyword | BRCA1/2 mutation carrier | - |
dc.subject.keyword | Breastfeeding | - |
dc.subject.keyword | Meta-analysis | - |
dc.subject.keyword | Ovarian cancer | - |
dc.subject.keyword | Systematic review | - |
dc.contributor.alternativeName | Nam, Eun Ji | - |
dc.contributor.affiliatedAuthor | 남은지 | - |
dc.contributor.affiliatedAuthor | 어경진 | - |
dc.citation.volume | 163 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 142 | - |
dc.citation.endPage | 147 | - |
dc.identifier.bibliographicCitation | GYNECOLOGIC ONCOLOGY, Vol.163(1) : 142-147, 2021-10 | - |
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