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Stem cell restores thalamocortical plasticity to rescue cognitive deficit in neonatal intraventricular hemorrhage
DC Field | Value | Language |
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dc.contributor.author | 고석진 | - |
dc.contributor.author | 정승수 | - |
dc.date.accessioned | 2021-12-28T17:08:50Z | - |
dc.date.available | 2021-12-28T17:08:50Z | - |
dc.date.issued | 2021-08 | - |
dc.identifier.issn | 0014-4886 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/186958 | - |
dc.description.abstract | Severe neonatal intraventricular hemorrhage (IVH) patients incur long-term neurologic deficits such as cognitive disabilities. Recently, the intraventricular transplantation of allogeneic human umbilical cord blood-derived mesenchymal stem cells (MSCs) has drawn attention as a therapeutic potential to treat severe IVH. However, its pathological synaptic mechanism is still elusive. We here demonstrated that the integration of the somatosensory input was significantly distorted by suppressing feed-forward inhibition (FFI) at the thalamocortical (TC) inputs in the barrel cortices of neonatal rats with IVH by using BOLD-fMRI signal and brain slice patch-clamp technique. This is induced by the suppression of Hebbian plasticity via an increase in tumor necrosis factor-α expression during the critical period, which can be effectively reversed by the transplantation of MSCs. Furthermore, we showed that MSC transplantation successfully rescued IVH-induced learning deficits in the sensory-guided decision-making in correlation with TC FFI in the layer 4 barrel cortex. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Academic Press | - |
dc.relation.isPartOf | EXPERIMENTAL NEUROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Animals, Newborn | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Cerebral Cortex / diagnostic imaging | - |
dc.subject.MESH | Cerebral Cortex / physiology* | - |
dc.subject.MESH | Cerebral Intraventricular Hemorrhage / diagnostic imaging | - |
dc.subject.MESH | Cerebral Intraventricular Hemorrhage / physiopathology | - |
dc.subject.MESH | Cerebral Intraventricular Hemorrhage / therapy* | - |
dc.subject.MESH | Cognitive Dysfunction / diagnostic imaging | - |
dc.subject.MESH | Cognitive Dysfunction / physiopathology | - |
dc.subject.MESH | Cognitive Dysfunction / therapy* | - |
dc.subject.MESH | Excitatory Postsynaptic Potentials / physiology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Inhibitory Postsynaptic Potentials / physiology | - |
dc.subject.MESH | Magnetic Resonance Imaging / methods | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mesenchymal Stem Cell Transplantation / methods* | - |
dc.subject.MESH | Neuronal Plasticity / physiology* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Thalamus / diagnostic imaging | - |
dc.subject.MESH | Thalamus / physiology* | - |
dc.title | Stem cell restores thalamocortical plasticity to rescue cognitive deficit in neonatal intraventricular hemorrhage | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학교실) | - |
dc.contributor.googleauthor | So Yoon Ahn | - |
dc.contributor.googleauthor | Hyesoo Jie | - |
dc.contributor.googleauthor | Won-Beom Jung | - |
dc.contributor.googleauthor | Ji-Hyun Jeong | - |
dc.contributor.googleauthor | Sukjin Ko | - |
dc.contributor.googleauthor | Geun Ho Im | - |
dc.contributor.googleauthor | Won Soon Park | - |
dc.contributor.googleauthor | Jung Hee Lee | - |
dc.contributor.googleauthor | Yun Sil Chang | - |
dc.contributor.googleauthor | Seungsoo Chung | - |
dc.identifier.doi | 10.1016/j.expneurol.2021.113736 | - |
dc.contributor.localId | A00120 | - |
dc.contributor.localId | A03643 | - |
dc.relation.journalcode | J00873 | - |
dc.identifier.eissn | 1090-2430 | - |
dc.identifier.pmid | 33945790 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0014488621001424 | - |
dc.subject.keyword | Barrel cortex | - |
dc.subject.keyword | Functional MRI (fMRI) | - |
dc.subject.keyword | Intraventricular hemorrhage | - |
dc.subject.keyword | Mesenchymal stem cell | - |
dc.subject.keyword | Sensory-guided decision making | - |
dc.subject.keyword | Thalamocortical input | - |
dc.contributor.alternativeName | Ko, Suk Jin | - |
dc.contributor.affiliatedAuthor | 고석진 | - |
dc.contributor.affiliatedAuthor | 정승수 | - |
dc.citation.volume | 342 | - |
dc.citation.startPage | 113736 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL NEUROLOGY, Vol.342 : 113736, 2021-08 | - |
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