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Vascular Uptake on 18 F-FDG PET/CT During the Clinically Inactive State of Takayasu Arteritis Is Associated with a Higher Risk of Relapse

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dc.contributor.author권오찬-
dc.contributor.author박민찬-
dc.contributor.author전태주-
dc.date.accessioned2021-12-28T17:07:47Z-
dc.date.available2021-12-28T17:07:47Z-
dc.date.issued2021-09-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/186949-
dc.description.abstractPurpose: To evaluate whether vascular uptake on 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) during the clinically inactive state of Takayasu arteritis (TAK) is associated with disease relapse. Materials and methods: Patients with TAK who underwent 18F-FDG PET/CT during the clinically inactive state of the disease between 2006 and 2019 were included. Clinically inactive disease was defined as a status not fulfilling the National Institutes of Health (NIH) criteria for active disease in TAK. Relapse was defined as recurrence of clinically active disease after a clinically inactive period, requiring change in the treatment regimen. Vascular uptake on 18F-FDG PET/CT was assessed using target/background ratio (TBR), calculated as arterial maximum standardized uptake value (SUV)/mean SUV in venous blood pool. Multivariable Cox regression analysis was performed to identify factors associated with relapse. Results: A total of 33 patients with clinically inactive TAK were included. During a median observation period of 4.5 (0.9-8.1) years, relapse occurred in 9 (27.3%) patients at median 1.3 (0.7-6.9) years. Notably, TBR [1.5 (1.3-1.8) vs. 1.3 (1.1-1.4), p=0.044] was significantly higher in patients who relapsed than in those who did not. On multivariable Cox regression analysis, the presence of NIH criterion 2 [adjusted hazard ratio (HR): 7.044 (1.424-34.855), p=0.017] and TBR [adjusted HR: 11.533 (1.053-126.282), p=0.045] were significantly associated with an increased risk of relapse. Conclusion: Vascular uptake on 18F-FDG PET/CT and the presence of NIH criterion 2 are associated with future relapse in patients with clinically inactive TAK.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHFluorodeoxyglucose F18*-
dc.subject.MESHHumans-
dc.subject.MESHPositron Emission Tomography Computed Tomography-
dc.subject.MESHRadiopharmaceuticals-
dc.subject.MESHRecurrence-
dc.subject.MESHTakayasu Arteritis* / diagnostic imaging-
dc.titleVascular Uptake on 18 F-FDG PET/CT During the Clinically Inactive State of Takayasu Arteritis Is Associated with a Higher Risk of Relapse-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorOh Chan Kwon-
dc.contributor.googleauthorTae Joo Jeon-
dc.contributor.googleauthorMin Chan Park-
dc.identifier.doi10.3349/ymj.2021.62.9.814-
dc.contributor.localIdA05818-
dc.contributor.localIdA01470-
dc.contributor.localIdA03557-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid34427067-
dc.subject.keywordPET/CT-
dc.subject.keywordTakayasu arteritis-
dc.subject.keywordinactive-
dc.subject.keywordrelapse-
dc.contributor.alternativeNameKwon, Oh Chan-
dc.contributor.affiliatedAuthor권오찬-
dc.contributor.affiliatedAuthor박민찬-
dc.contributor.affiliatedAuthor전태주-
dc.citation.volume62-
dc.citation.number9-
dc.citation.startPage814-
dc.citation.endPage821-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.62(9) : 814-821, 2021-09-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers

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