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Internal mammary node irradiation in node-positive breast cancer treated with mastectomy and taxane-based chemotherapy
DC Field | Value | Language |
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dc.contributor.author | 김용배 | - |
dc.contributor.author | 장지석 | - |
dc.date.accessioned | 2021-12-28T16:59:13Z | - |
dc.date.available | 2021-12-28T16:59:13Z | - |
dc.date.issued | 2021-10 | - |
dc.identifier.issn | 0960-9776 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/186880 | - |
dc.description.abstract | Background: It is important to continually reevaluate the risk/benefit calculus of internal mammary node irradiation (IMNI) in the era of modern systemic therapy. We aimed to investigate the effect of IMNI on survival in node-positive breast cancer treated with mastectomy and anthracycline plus taxane-based chemotherapy. Methods: We analyzed 348 patients who underwent mastectomy and anthracycline plus taxane-based chemotherapy for node-positive breast cancer between January 2006 and December 2011. All patients received postoperative radiation therapy (RT) with IMNI (n = 105, 30.2%) or without IMNI (n = 243, 69.8%). The benefit of IMNI for disease-free survival (DFS) and overall survival (OS) was evaluated using multivariate analysis and inverse probability of treatment weighting (IPTW) to adjust for unbalanced covariates between the groups. Results: After a median follow-up of 95 months, the 10-year locoregional recurrence-free survival rate, DFS, and OS in all patients were 94.8%, 77.4%, and 86.2%, respectively. The IPTW-adjusted hazard ratio (HR) for the association of IMNI (vs. no IMNI) with DFS and OS was 0.208 (95% confidence intervals (CI) 0.045-0.966) and 0.460 (95% CI, 0.220-0.962), respectively. In multivariate analysis, IMNI was a favorable factor for DFS (HR, 0.458; P = 0.021) and OS (HR 0.233, P = 0.018). Conclusions: IMNI was associated with improved DFS and OS in node-positive patients treated with mastectomy, post-mastectomy RT, and taxane-based chemotherapy, although the rate of locoregional recurrence was low. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | BREAST | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Breast Neoplasms* / drug therapy | - |
dc.subject.MESH | Chemotherapy, Adjuvant | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lymph Nodes | - |
dc.subject.MESH | Mastectomy* | - |
dc.subject.MESH | Neoplasm Recurrence, Local | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Taxoids / therapeutic use | - |
dc.title | Internal mammary node irradiation in node-positive breast cancer treated with mastectomy and taxane-based chemotherapy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학교실) | - |
dc.contributor.googleauthor | Won Kyung Cho | - |
dc.contributor.googleauthor | Jee Suk Chang | - |
dc.contributor.googleauthor | Seung Gyu Park | - |
dc.contributor.googleauthor | Nalee Kim | - |
dc.contributor.googleauthor | Doo Ho Choi | - |
dc.contributor.googleauthor | Haeyoung Kim | - |
dc.contributor.googleauthor | Yong Bae Kim | - |
dc.contributor.googleauthor | Won Park | - |
dc.contributor.googleauthor | Chang Ok Suh | - |
dc.identifier.doi | 10.1016/j.breast.2021.05.012 | - |
dc.contributor.localId | A00744 | - |
dc.contributor.localId | A04658 | - |
dc.relation.journalcode | J00400 | - |
dc.identifier.eissn | 1532-3080 | - |
dc.identifier.pmid | 34126377 | - |
dc.subject.keyword | Internal mammary node | - |
dc.subject.keyword | Radiation | - |
dc.subject.keyword | Regional lymph node irradiation | - |
dc.contributor.alternativeName | Kim, Yong Bae | - |
dc.contributor.affiliatedAuthor | 김용배 | - |
dc.contributor.affiliatedAuthor | 장지석 | - |
dc.citation.volume | 59 | - |
dc.citation.startPage | 37 | - |
dc.citation.endPage | 43 | - |
dc.identifier.bibliographicCitation | BREAST, Vol.59 : 37-43, 2021-10 | - |
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