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Neuropsychiatric Burden Is a Predictor of Early Freezing and Motor Progression in Drug-Naïve Parkinson's Disease
DC Field | Value | Language |
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dc.contributor.author | 백경원 | - |
dc.contributor.author | 손영호 | - |
dc.contributor.author | 이양현 | - |
dc.contributor.author | 이필휴 | - |
dc.contributor.author | 정석종 | - |
dc.contributor.author | 유한수 | - |
dc.date.accessioned | 2021-12-28T16:57:20Z | - |
dc.date.available | 2021-12-28T16:57:20Z | - |
dc.date.issued | 2021-10 | - |
dc.identifier.issn | 1877-7171 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/186869 | - |
dc.description.abstract | Background: Neuropsychiatric symptoms (NPS) are the most common non-motor symptom in Parkinson's disease (PD). Objective: To investigate the association between the burden of NPS and motor prognosis in patients with PD. Methods: We enrolled 329 drug-naïve patients with PD, who was non-demented and followed-up≥2 years after their first visit to the clinic with baseline dopamine transporter (DAT) imaging and neuropsychiatric inventory (NPI) scores. We performed a survival analysis and a linear mixed model analysis to assess longitudinal motor outcomes according to the NPI total score. Results: The Kaplan-Meier analysis showed no difference in the development of levodopa-induced dyskinesia and wearing-off according to the NPI total score. However, higher burden of NPI total score was associated with earlier freezing of gait (FOG) development in the time-dependent Cox regression models after adjusting for age at symptom onset, sex, disease duration, Unified PD Rating Scale motor score, baseline Mini-Mental State Examination score, DAT activity in the posterior putamen and levodopa-equivalent daily dose (LEDD) (Hazard ratio 1.047, p = 0.002). A linear mixed model analysis revealed that patients with a higher NPI total score had a more rapid LEDD increment (NPI×time, p = 0.003). Among 52 patients with PD who eventually developed FOG during the follow-up period, there was a significant correlation between the NPI total score and time with FOG development (γ= -0.472; p = 0.001) after adjusting for confounding factors. Conclusion: The present study demonstrated that the severity of NPS is a predictor of early freezing and motor progression in patients with PD. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | IOS Press | - |
dc.relation.isPartOf | JOURNAL OF PARKINSONS DISEASE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Neuropsychiatric Burden Is a Predictor of Early Freezing and Motor Progression in Drug-Naïve Parkinson's Disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Seong Ho Jeong | - |
dc.contributor.googleauthor | Han Soo Yoo | - |
dc.contributor.googleauthor | Seok Jong Chung | - |
dc.contributor.googleauthor | Jin Ho Jung | - |
dc.contributor.googleauthor | Yang Hyun Lee | - |
dc.contributor.googleauthor | Kyoungwon Baik | - |
dc.contributor.googleauthor | Young H Sohn | - |
dc.contributor.googleauthor | Phil Hyu Lee | - |
dc.identifier.doi | 10.3233/JPD-212660 | - |
dc.contributor.localId | A05133 | - |
dc.contributor.localId | A01982 | - |
dc.contributor.localId | A05714 | - |
dc.contributor.localId | A03270 | - |
dc.contributor.localId | A04666 | - |
dc.relation.journalcode | J01678 | - |
dc.identifier.eissn | 1877-718X | - |
dc.identifier.pmid | 34151858 | - |
dc.identifier.url | https://content.iospress.com/articles/journal-of-parkinsons-disease/jpd212660 | - |
dc.subject.keyword | Parkinson’s disease | - |
dc.subject.keyword | motor prognosis | - |
dc.subject.keyword | neuropsychiatric symptoms | - |
dc.contributor.alternativeName | Baik, Kyoungwon | - |
dc.contributor.affiliatedAuthor | 백경원 | - |
dc.contributor.affiliatedAuthor | 손영호 | - |
dc.contributor.affiliatedAuthor | 이양현 | - |
dc.contributor.affiliatedAuthor | 이필휴 | - |
dc.contributor.affiliatedAuthor | 정석종 | - |
dc.citation.volume | 11 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1947 | - |
dc.citation.endPage | 1956 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PARKINSONS DISEASE, Vol.11(4) : 1947-1956, 2021-10 | - |
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