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Aberrant Expression of Sodium-Potassium-Chloride Cotransporter in Endometriosis

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dc.contributor.author김희연-
dc.contributor.author박주현-
dc.contributor.author서석교-
dc.contributor.author윤보현-
dc.contributor.author이병석-
dc.contributor.author이인하-
dc.contributor.author이재훈-
dc.contributor.author조시현-
dc.contributor.author최영식-
dc.contributor.author김희연-
dc.contributor.author박주현-
dc.contributor.author서석교-
dc.contributor.author윤보현-
dc.contributor.author이병석-
dc.contributor.author이인하-
dc.contributor.author이재훈-
dc.contributor.author조시현-
dc.contributor.author최영식-
dc.date.accessioned2021-12-28T16:57:05Z-
dc.date.available2021-12-28T16:57:05Z-
dc.date.issued2021-09-
dc.identifier.issn1933-7191-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/186868-
dc.description.abstractCell membrane ion channels have important roles in cell migration during cancer development and metastasis. Although endometriosis is a benign gynecological disease, some migration and invasion characteristics of endometriosis are similar to those of cancer. However, only a few studies have examined cell membrane ion channels and their associations with endometriosis. This study aimed to investigate the effects of these ion channels on development of endometriosis. A total of 39 women who underwent laparoscopic ovarian cyst enucleation were included in the study population. Eutopic endometrium or ectopic endometrium tissues were obtained from each patient based on allocation to an endometriosis group (n=21) or a control group (n=18). Quantitative real-time PCR (qRT-PCR) and western blot analyses were performed to quantify NKCC1, NKCC2, and CLCN3 mRNA expression and protein concentrations. SiRNA transfection and migration assays of the endometrial stromal cells were performed to test the effects of the ion channels on the migration ability. The qRT-PCR and western blot analyses revealed significantly elevated mRNA expression and protein expression of NKCC1, NKCC2, and CLCN3 in the ectopic endometrial tissue from the patients with endometriosis (p < 0.05). Migration assay of siRNA transfected cells suggested a decreased migratory potential of the endometrial stromal cells (p < 0.001). The magnitudes of expression of NKCC1, NKCC2, and CLCN3 were positively correlated with endometrioma size. The increased expression of NKCC1, NKCC2, and CLCN3 in endometriosis offers opportunities to understand mechanisms of endometriosis and develop novel therapeutic approaches.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSage-
dc.relation.isPartOfREPRODUCTIVE SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleAberrant Expression of Sodium-Potassium-Chloride Cotransporter in Endometriosis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Obstetrics and Gynecology (산부인과학교실)-
dc.contributor.googleauthorInha Lee-
dc.contributor.googleauthorMyung Jae Jeon-
dc.contributor.googleauthorJeong Sook Kim-
dc.contributor.googleauthorJi Hyun Park-
dc.contributor.googleauthorBo Hee Won-
dc.contributor.googleauthorHeeyon Kim-
dc.contributor.googleauthorJae Hoon Lee-
dc.contributor.googleauthorBo Hyon Yun-
dc.contributor.googleauthorJoo Hyun Park-
dc.contributor.googleauthorSeok Kyo Seo-
dc.contributor.googleauthorYoung Sik Choi-
dc.contributor.googleauthorSiHyun Cho-
dc.contributor.googleauthorByung Seok Lee-
dc.identifier.doi10.1007/s43032-021-00531-4-
dc.contributor.localIdA06072-
dc.contributor.localIdA01668-
dc.contributor.localIdA01888-
dc.contributor.localIdA02555-
dc.contributor.localIdA02795-
dc.contributor.localIdA05497-
dc.contributor.localIdA04636-
dc.contributor.localIdA03846-
dc.contributor.localIdA04114-
dc.contributor.localIdA06072-
dc.contributor.localIdA01668-
dc.contributor.localIdA01888-
dc.contributor.localIdA02555-
dc.contributor.localIdA02795-
dc.contributor.localIdA05497-
dc.contributor.localIdA04636-
dc.contributor.localIdA03846-
dc.contributor.localIdA04114-
dc.relation.journalcodeJ02606-
dc.identifier.eissn1933-7205-
dc.identifier.pmid33709377-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs43032-021-00531-4-
dc.subject.keywordCell migration-
dc.subject.keywordEndometriosis-
dc.subject.keywordMembrane channel-
dc.subject.keywordNKCC-
dc.contributor.alternativeNameKim, Heeyon-
dc.contributor.affiliatedAuthor김희연-
dc.contributor.affiliatedAuthor박주현-
dc.contributor.affiliatedAuthor서석교-
dc.contributor.affiliatedAuthor윤보현-
dc.contributor.affiliatedAuthor이병석-
dc.contributor.affiliatedAuthor이인하-
dc.contributor.affiliatedAuthor이재훈-
dc.contributor.affiliatedAuthor조시현-
dc.contributor.affiliatedAuthor최영식-
dc.contributor.affiliatedAuthor김희연-
dc.contributor.affiliatedAuthor박주현-
dc.contributor.affiliatedAuthor서석교-
dc.contributor.affiliatedAuthor윤보현-
dc.contributor.affiliatedAuthor이병석-
dc.contributor.affiliatedAuthor이인하-
dc.contributor.affiliatedAuthor이재훈-
dc.contributor.affiliatedAuthor조시현-
dc.contributor.affiliatedAuthor최영식-
dc.citation.volume28-
dc.citation.number9-
dc.citation.startPage2641-
dc.citation.endPage2648-
dc.identifier.bibliographicCitationREPRODUCTIVE SCIENCES, Vol.28(9) : 2641-2648, 2021-09-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers

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