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Pan-Cancer Analysis of Clinical Relevance via Telomere Maintenance Mechanism

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dc.contributor.author정재호-
dc.contributor.author정재호-
dc.date.accessioned2021-12-28T16:56:26Z-
dc.date.available2021-12-28T16:56:26Z-
dc.date.issued2021-10-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/186862-
dc.description.abstractUnderstanding the telomere maintenance mechanism (TMM) in immortal cancer cells is vital for TMM-targeted therapies in clinical settings. In this study, we classified four telomere maintenance mechanisms into telomerase, ALT, telomerase + ALT, and non-defined telomere maintenance mechanism (NDTMM) across 31 cancer types using 10,704 transcriptomic datasets from The Cancer Genome Atlas. Our results demonstrated that approximately 50% of the total cohort displayed ALT activity with high telomerase activity in most cancer types. We confirmed significant patient prognoses according to distinct TMMs in six cancer types: adrenocortical carcinoma (ACC), PAAD, HNSC, SARC, GBM, and metastatic cancer. Patients with metastasis had a poor prognosis in the ALT group (p < 0.006) subjected to RAS protein signal transduction. Glioblastoma patients had poor prognosis in NDTMM (p < 0.0043) and showed high levels of myeloid leukocyte activation. Pancreatic adenocarcinoma (p < 0.04) and head and neck squamous cell carcinoma (p < 0.046) patients had a good prognosis in the ALT group with high immune cell activation. Furthermore, we showed that master transcriptional regulators might affect the selection of the TMM pathway and explained why different telomere maintenance mechanisms exist. Furthermore, they can be used to segregate patients and predict responders to different TMM-targeted therapeutics.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titlePan-Cancer Analysis of Clinical Relevance via Telomere Maintenance Mechanism-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorJi-Yong Sung-
dc.contributor.googleauthorJae-Ho Cheong-
dc.identifier.doi10.3390/ijms222011101-
dc.contributor.localIdA03717-
dc.contributor.localIdA03717-
dc.relation.journalcodeJ01133-
dc.identifier.eissn1422-0067-
dc.identifier.pmid34681758-
dc.subject.keywordalternative lengthening of telomere-
dc.subject.keywordnon-defined telomere maintenance mechanism-
dc.subject.keywordtelomere maintenance mechanism-
dc.contributor.alternativeNameCheong, Jae Ho-
dc.contributor.affiliatedAuthor정재호-
dc.contributor.affiliatedAuthor정재호-
dc.citation.volume22-
dc.citation.number20-
dc.citation.startPage11101-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.22(20) : 11101, 2021-10-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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