175 420

Cited 0 times in

Development of a Margin Determination Framework for Tumor-Tracking Radiation Therapy With Intraoperatively Implanted Fiducial Markers

DC Field Value Language
dc.contributor.author금웅섭-
dc.contributor.author김경환-
dc.contributor.author김지훈-
dc.contributor.author김진성-
dc.contributor.author박성용-
dc.contributor.author변화경-
dc.contributor.author장지석-
dc.contributor.author한민철-
dc.contributor.author홍채선-
dc.date.accessioned2021-12-28T16:53:50Z-
dc.date.available2021-12-28T16:53:50Z-
dc.date.issued2021-10-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/186841-
dc.description.abstractPurpose: To develop an internal target volume (ITV) margin determination framework (or decision-supporting framework) for treating multiple lung metastases using CyberKnife Synchrony with intraoperatively implanted fiducial markers (IIFMs). The feasibility of using non-ideally implanted fiducial markers (a limited number and/or far from a target) for tracking-based lung stereotactic ablative radiotherapy (SABR) was investigated. Methods: In the developed margin determination framework, an optimal set of IIFMs was determined to minimize a tracking uncertainty-specific ITV (ITVtracking) margin (margin required to cover target-to-marker motion discrepancy), i.e., minimize the motion discrepancies between gross tumor volume (GTV) and the selected set of fiducial markers (FMs). The developed margin determination framework was evaluated in 17 patients with lung metastases. To automatically calculate the respiratory motions of the FMs, a template matching-based FM tracking algorithm was developed, and GTV motion was manually measured. Furthermore, during-treatment motions of the selected FMs were analyzed using log files and compared with those calculated using 4D CTs. Results: For 41 of 42 lesions in 17 patients (97.6%), an optimal set of the IIFMs was successfully determined, requiring an ITVtracking margin less than 5 mm. The template matching-based FM tracking algorithm calculated the FM motions with a sub-millimeter accuracy compared with the manual measurements. The patient respiratory motions during treatment were, on average, significantly smaller than those measured at simulation for the patient cohort considered. Conclusion: Use of the developed margin determination framework employing CyberKnife Synchrony with a limited number of IIFMs is feasible for lung SABR.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherFrontiers Research Foundation-
dc.relation.isPartOfFRONTIERS IN ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleDevelopment of a Margin Determination Framework for Tumor-Tracking Radiation Therapy With Intraoperatively Implanted Fiducial Markers-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학교실)-
dc.contributor.googleauthorJihun Kim-
dc.contributor.googleauthorMin Cheol Han-
dc.contributor.googleauthorJee Suk Chang-
dc.contributor.googleauthorChae-Seon Hong-
dc.contributor.googleauthorKyung Hwan Kim-
dc.contributor.googleauthorHwa Kyung Byun-
dc.contributor.googleauthorRyeong Hwang Park-
dc.contributor.googleauthorWoong Sub Koom-
dc.contributor.googleauthorSeong Yong Park-
dc.contributor.googleauthorJin Sung Kim-
dc.identifier.doi10.3389/fonc.2021.753246-
dc.contributor.localIdA00273-
dc.contributor.localIdA05226-
dc.contributor.localIdA05823-
dc.contributor.localIdA04548-
dc.contributor.localIdA01508-
dc.contributor.localIdA05136-
dc.contributor.localIdA04658-
dc.contributor.localIdA05870-
dc.contributor.localIdA05846-
dc.relation.journalcodeJ03512-
dc.identifier.eissn2234-943X-
dc.identifier.pmid34692536-
dc.subject.keywordCyberKnife Synchrony-
dc.subject.keywordfiducial tracking-
dc.subject.keywordinternal target volume-
dc.subject.keywordintraoperative fiducial marker implantation-
dc.subject.keywordlung metastasis-
dc.subject.keywordstereotactic ablative radiotherapy-
dc.contributor.alternativeNameKoom, Woong Sub-
dc.contributor.affiliatedAuthor금웅섭-
dc.contributor.affiliatedAuthor김경환-
dc.contributor.affiliatedAuthor김지훈-
dc.contributor.affiliatedAuthor김진성-
dc.contributor.affiliatedAuthor박성용-
dc.contributor.affiliatedAuthor변화경-
dc.contributor.affiliatedAuthor장지석-
dc.contributor.affiliatedAuthor한민철-
dc.contributor.affiliatedAuthor홍채선-
dc.citation.volume11-
dc.citation.startPage753246-
dc.identifier.bibliographicCitationFRONTIERS IN ONCOLOGY, Vol.11 : 753246, 2021-10-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.