227 422

Cited 0 times in

Proteoglycan Combined with Hyaluronic Acid and Hydrolyzed Collagen Restores the Skin Barrier in Mild Atopic Dermatitis and Dry, Eczema-Prone Skin: A Pilot Study

DC Field Value Language
dc.contributor.author김제민-
dc.contributor.author이영인-
dc.contributor.author이주희-
dc.date.accessioned2021-12-28T16:53:13Z-
dc.date.available2021-12-28T16:53:13Z-
dc.date.issued2021-09-
dc.identifier.issn1661-6596-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/186837-
dc.description.abstractDry and eczema-prone skin conditions such as atopic dermatitis and xerotic eczema primarily indicate an impaired skin barrier function, which leads to chronic pruritus. Here, we investigated the effects of a novel emollient containing H.ECMTM liposome, which contains a soluble proteoglycan in combination with hydrolyzed collagen and hyaluronic acid. A prospective, single-arm study was conducted on 25 participants with mild atopic dermatitis or dry skin to assess the hydration and anti-inflammatory effect of the novel emollient applied daily over four weeks. All efficacy parameters, including itching severity, transepidermal water loss, and skin hydration, improved significantly after four weeks. The in vitro and ex vivo studies confirmed the restoration of the skin's barrier function. The study revealed the clinical and laboratory efficacy of H.ECMTM liposome in reducing itching and improving the skin's barrier integrity. Thus, the use of H.ECMTM liposome can be considered a therapeutic option for dry and eczema-prone skin.-
dc.description.statementOfResponsibilityopen-
dc.languageINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.publisherINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdministration, Topical-
dc.subject.MESHAdult-
dc.subject.MESHAnimals-
dc.subject.MESHAnti-Inflammatory Agents / administration & dosage-
dc.subject.MESHAnti-Inflammatory Agents / pharmacology*-
dc.subject.MESHCell Line-
dc.subject.MESHCollagen / administration & dosage-
dc.subject.MESHCollagen / pharmacology*-
dc.subject.MESHDermatitis, Atopic / drug therapy*-
dc.subject.MESHDermatitis, Atopic / pathology-
dc.subject.MESHEczema / drug therapy*-
dc.subject.MESHEmollients / pharmacology-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHyaluronic Acid / administration & dosage-
dc.subject.MESHHyaluronic Acid / pharmacology*-
dc.subject.MESHIchthyosis / drug therapy-
dc.subject.MESHLiposomes / chemistry-
dc.subject.MESHLiposomes / pharmacology-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPilot Projects-
dc.subject.MESHProteoglycans / administration & dosage-
dc.subject.MESHProteoglycans / pharmacology*-
dc.subject.MESHPruritus / drug therapy-
dc.subject.MESHRAW 264.7 Cells-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHSkin / drug effects-
dc.subject.MESHSkin / pathology-
dc.subject.MESHWater Loss, Insensible / drug effects-
dc.subject.MESHYoung Adult-
dc.titleProteoglycan Combined with Hyaluronic Acid and Hydrolyzed Collagen Restores the Skin Barrier in Mild Atopic Dermatitis and Dry, Eczema-Prone Skin: A Pilot Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Dermatology (피부과학교실)-
dc.contributor.googleauthorYoung In Lee-
dc.contributor.googleauthorSang Gyu Lee-
dc.contributor.googleauthorJemin Kim-
dc.contributor.googleauthorSooyeon Choi-
dc.contributor.googleauthorInhee Jung-
dc.contributor.googleauthorJu Hee Lee-
dc.identifier.doi10.3390/ijms221910189-
dc.contributor.localIdA05725-
dc.contributor.localIdA05880-
dc.contributor.localIdA03171-
dc.relation.journalcodeJ01133-
dc.identifier.eissn1422-0067-
dc.identifier.pmid34638528-
dc.subject.keyworddry skin-
dc.subject.keywordeczema-
dc.subject.keywordhydration-
dc.subject.keywordliposome-
dc.subject.keywordproteoglycan-
dc.subject.keywordskin barrier-
dc.contributor.alternativeNameKim, Jemin-
dc.contributor.affiliatedAuthor김제민-
dc.contributor.affiliatedAuthor이영인-
dc.contributor.affiliatedAuthor이주희-
dc.citation.volume22-
dc.citation.number19-
dc.citation.startPage10189-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.22(19) : 10189, 2021-09-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.