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Proteoglycan Combined with Hyaluronic Acid and Hydrolyzed Collagen Restores the Skin Barrier in Mild Atopic Dermatitis and Dry, Eczema-Prone Skin: A Pilot Study
DC Field | Value | Language |
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dc.contributor.author | 김제민 | - |
dc.contributor.author | 이영인 | - |
dc.contributor.author | 이주희 | - |
dc.date.accessioned | 2021-12-28T16:53:13Z | - |
dc.date.available | 2021-12-28T16:53:13Z | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/186837 | - |
dc.description.abstract | Dry and eczema-prone skin conditions such as atopic dermatitis and xerotic eczema primarily indicate an impaired skin barrier function, which leads to chronic pruritus. Here, we investigated the effects of a novel emollient containing H.ECMTM liposome, which contains a soluble proteoglycan in combination with hydrolyzed collagen and hyaluronic acid. A prospective, single-arm study was conducted on 25 participants with mild atopic dermatitis or dry skin to assess the hydration and anti-inflammatory effect of the novel emollient applied daily over four weeks. All efficacy parameters, including itching severity, transepidermal water loss, and skin hydration, improved significantly after four weeks. The in vitro and ex vivo studies confirmed the restoration of the skin's barrier function. The study revealed the clinical and laboratory efficacy of H.ECMTM liposome in reducing itching and improving the skin's barrier integrity. Thus, the use of H.ECMTM liposome can be considered a therapeutic option for dry and eczema-prone skin. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.publisher | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Administration, Topical | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Anti-Inflammatory Agents / administration & dosage | - |
dc.subject.MESH | Anti-Inflammatory Agents / pharmacology* | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Collagen / administration & dosage | - |
dc.subject.MESH | Collagen / pharmacology* | - |
dc.subject.MESH | Dermatitis, Atopic / drug therapy* | - |
dc.subject.MESH | Dermatitis, Atopic / pathology | - |
dc.subject.MESH | Eczema / drug therapy* | - |
dc.subject.MESH | Emollients / pharmacology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hyaluronic Acid / administration & dosage | - |
dc.subject.MESH | Hyaluronic Acid / pharmacology* | - |
dc.subject.MESH | Ichthyosis / drug therapy | - |
dc.subject.MESH | Liposomes / chemistry | - |
dc.subject.MESH | Liposomes / pharmacology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Pilot Projects | - |
dc.subject.MESH | Proteoglycans / administration & dosage | - |
dc.subject.MESH | Proteoglycans / pharmacology* | - |
dc.subject.MESH | Pruritus / drug therapy | - |
dc.subject.MESH | RAW 264.7 Cells | - |
dc.subject.MESH | Severity of Illness Index | - |
dc.subject.MESH | Skin / drug effects | - |
dc.subject.MESH | Skin / pathology | - |
dc.subject.MESH | Water Loss, Insensible / drug effects | - |
dc.subject.MESH | Young Adult | - |
dc.title | Proteoglycan Combined with Hyaluronic Acid and Hydrolyzed Collagen Restores the Skin Barrier in Mild Atopic Dermatitis and Dry, Eczema-Prone Skin: A Pilot Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학교실) | - |
dc.contributor.googleauthor | Young In Lee | - |
dc.contributor.googleauthor | Sang Gyu Lee | - |
dc.contributor.googleauthor | Jemin Kim | - |
dc.contributor.googleauthor | Sooyeon Choi | - |
dc.contributor.googleauthor | Inhee Jung | - |
dc.contributor.googleauthor | Ju Hee Lee | - |
dc.identifier.doi | 10.3390/ijms221910189 | - |
dc.contributor.localId | A05725 | - |
dc.contributor.localId | A05880 | - |
dc.contributor.localId | A03171 | - |
dc.relation.journalcode | J01133 | - |
dc.identifier.eissn | 1422-0067 | - |
dc.identifier.pmid | 34638528 | - |
dc.subject.keyword | dry skin | - |
dc.subject.keyword | eczema | - |
dc.subject.keyword | hydration | - |
dc.subject.keyword | liposome | - |
dc.subject.keyword | proteoglycan | - |
dc.subject.keyword | skin barrier | - |
dc.contributor.alternativeName | Kim, Jemin | - |
dc.contributor.affiliatedAuthor | 김제민 | - |
dc.contributor.affiliatedAuthor | 이영인 | - |
dc.contributor.affiliatedAuthor | 이주희 | - |
dc.citation.volume | 22 | - |
dc.citation.number | 19 | - |
dc.citation.startPage | 10189 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.22(19) : 10189, 2021-09 | - |
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