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Low Ankle-Brachial Index Is Associated With Stroke Recurrence in Ischemic Stroke Patients With Atrial Fibrillation

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dc.contributor.author김영대-
dc.contributor.author남효석-
dc.contributor.author백민렬-
dc.contributor.author허지회-
dc.contributor.author김영대-
dc.contributor.author남효석-
dc.contributor.author백민렬-
dc.contributor.author허지회-
dc.contributor.author박은정-
dc.date.accessioned2021-12-28T16:51:20Z-
dc.date.available2021-12-28T16:51:20Z-
dc.date.issued2021-10-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/186824-
dc.description.abstractIntroduction: Cardioembolic stroke (CE) has poor outcomes and high recurrence rates. A low ankle-brachial index (ABI <0.9) is associated with atrial fibrillation (AF) and poor stroke outcomes. We investigated whether a low ABI is associated with stroke recurrence, major adverse cardiovascular events (MACE), and mortality in patients with CE and whether this association is affected by AF. Methods: We enrolled patients with CE who underwent ABI measurements during hospitalization. Recurrent stroke was defined based on newly developed neurologic symptoms with relevant lesions 7 days after the index stroke. MACE comprised stroke recurrence, myocardial infarction, or death. Results: Of 775 patients, 427 (55.1%) were AF patients and 348 (44.9%) were non-AF patients. Patients were followed up for a median of 33.6 (IQR, 18.0-51.6) months. In total, 194 (25.0%) patients experienced MACE, including 77 (9.9%) patients with stroke recurrence and 101 (13.0%) patients with mortality, during the study period. Multivariable Cox regression analysis showed that an ABI <0.9 was independently associated with MACE (AF patients: hazard ratio [HR] = 2.327, 95% confidence interval [CI] = 1.371-3.949, non-AF patients: HR = 3.116, 95% CI = 1.465-6.629) and mortality (AF patients: HR = 2.659, 95% CI = 1.483-4.767, non-AF patients: HR = 3.645, 95% CI = 1.623-8.187). Stroke recurrence was independently associated with an ABI <0.9 in AF patients (HR = 3.559, 95% CI = 1.570-8.066), but not in non-AF patients (HR = 1.186, 95% CI = 0.156-8.989). Conclusions: We found that a low ABI is associated with stroke recurrence, MACE, and mortality in patients with CE. In particular, the association between ABI and recurrent stroke is only present in AF patients. A low ABI may be a useful prognostic marker in patients with CE, especially in AF patients.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherFrontiers Research Foundation-
dc.relation.isPartOfFRONTIERS IN NEUROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleLow Ankle-Brachial Index Is Associated With Stroke Recurrence in Ischemic Stroke Patients With Atrial Fibrillation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorMinho Han-
dc.contributor.googleauthorMinyoul Baik-
dc.contributor.googleauthorYoung Dae Kim-
dc.contributor.googleauthorJunghye Choi-
dc.contributor.googleauthorKangsik Seo-
dc.contributor.googleauthorEunjeong Park-
dc.contributor.googleauthorJi Hoe Heo-
dc.contributor.googleauthorHyo Suk Nam-
dc.identifier.doi10.3389/fneur.2021.705904-
dc.contributor.localIdA00702-
dc.contributor.localIdA01273-
dc.contributor.localIdA05987-
dc.contributor.localIdA04369-
dc.contributor.localIdA00702-
dc.contributor.localIdA01273-
dc.contributor.localIdA05987-
dc.contributor.localIdA04369-
dc.relation.journalcodeJ02996-
dc.identifier.eissn1664-2295-
dc.identifier.pmid34744961-
dc.subject.keywordankle-brachial index-
dc.subject.keywordatrial fibrillation-
dc.subject.keywordoutcome-
dc.subject.keywordperipheral artery disease-
dc.subject.keywordstroke-
dc.contributor.alternativeNameKim, Young Dae-
dc.contributor.affiliatedAuthor김영대-
dc.contributor.affiliatedAuthor남효석-
dc.contributor.affiliatedAuthor백민렬-
dc.contributor.affiliatedAuthor허지회-
dc.contributor.affiliatedAuthor김영대-
dc.contributor.affiliatedAuthor남효석-
dc.contributor.affiliatedAuthor백민렬-
dc.contributor.affiliatedAuthor허지회-
dc.citation.volume12-
dc.citation.startPage705904-
dc.identifier.bibliographicCitationFRONTIERS IN NEUROLOGY, Vol.12 : 705904, 2021-10-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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