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Low Ankle-Brachial Index Is Associated With Stroke Recurrence in Ischemic Stroke Patients With Atrial Fibrillation
DC Field | Value | Language |
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dc.contributor.author | 김영대 | - |
dc.contributor.author | 남효석 | - |
dc.contributor.author | 백민렬 | - |
dc.contributor.author | 허지회 | - |
dc.contributor.author | 박은정 | - |
dc.date.accessioned | 2021-12-28T16:51:20Z | - |
dc.date.available | 2021-12-28T16:51:20Z | - |
dc.date.issued | 2021-10 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/186824 | - |
dc.description.abstract | Introduction: Cardioembolic stroke (CE) has poor outcomes and high recurrence rates. A low ankle-brachial index (ABI <0.9) is associated with atrial fibrillation (AF) and poor stroke outcomes. We investigated whether a low ABI is associated with stroke recurrence, major adverse cardiovascular events (MACE), and mortality in patients with CE and whether this association is affected by AF. Methods: We enrolled patients with CE who underwent ABI measurements during hospitalization. Recurrent stroke was defined based on newly developed neurologic symptoms with relevant lesions 7 days after the index stroke. MACE comprised stroke recurrence, myocardial infarction, or death. Results: Of 775 patients, 427 (55.1%) were AF patients and 348 (44.9%) were non-AF patients. Patients were followed up for a median of 33.6 (IQR, 18.0-51.6) months. In total, 194 (25.0%) patients experienced MACE, including 77 (9.9%) patients with stroke recurrence and 101 (13.0%) patients with mortality, during the study period. Multivariable Cox regression analysis showed that an ABI <0.9 was independently associated with MACE (AF patients: hazard ratio [HR] = 2.327, 95% confidence interval [CI] = 1.371-3.949, non-AF patients: HR = 3.116, 95% CI = 1.465-6.629) and mortality (AF patients: HR = 2.659, 95% CI = 1.483-4.767, non-AF patients: HR = 3.645, 95% CI = 1.623-8.187). Stroke recurrence was independently associated with an ABI <0.9 in AF patients (HR = 3.559, 95% CI = 1.570-8.066), but not in non-AF patients (HR = 1.186, 95% CI = 0.156-8.989). Conclusions: We found that a low ABI is associated with stroke recurrence, MACE, and mortality in patients with CE. In particular, the association between ABI and recurrent stroke is only present in AF patients. A low ABI may be a useful prognostic marker in patients with CE, especially in AF patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Frontiers Research Foundation | - |
dc.relation.isPartOf | FRONTIERS IN NEUROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Low Ankle-Brachial Index Is Associated With Stroke Recurrence in Ischemic Stroke Patients With Atrial Fibrillation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Minho Han | - |
dc.contributor.googleauthor | Minyoul Baik | - |
dc.contributor.googleauthor | Young Dae Kim | - |
dc.contributor.googleauthor | Junghye Choi | - |
dc.contributor.googleauthor | Kangsik Seo | - |
dc.contributor.googleauthor | Eunjeong Park | - |
dc.contributor.googleauthor | Ji Hoe Heo | - |
dc.contributor.googleauthor | Hyo Suk Nam | - |
dc.identifier.doi | 10.3389/fneur.2021.705904 | - |
dc.contributor.localId | A00702 | - |
dc.contributor.localId | A01273 | - |
dc.contributor.localId | A05987 | - |
dc.contributor.localId | A04369 | - |
dc.relation.journalcode | J02996 | - |
dc.identifier.eissn | 1664-2295 | - |
dc.identifier.pmid | 34744961 | - |
dc.subject.keyword | ankle-brachial index | - |
dc.subject.keyword | atrial fibrillation | - |
dc.subject.keyword | outcome | - |
dc.subject.keyword | peripheral artery disease | - |
dc.subject.keyword | stroke | - |
dc.contributor.alternativeName | Kim, Young Dae | - |
dc.contributor.affiliatedAuthor | 김영대 | - |
dc.contributor.affiliatedAuthor | 남효석 | - |
dc.contributor.affiliatedAuthor | 백민렬 | - |
dc.contributor.affiliatedAuthor | 허지회 | - |
dc.citation.volume | 12 | - |
dc.citation.startPage | 705904 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN NEUROLOGY, Vol.12 : 705904, 2021-10 | - |
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