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Increasing prescription of renin-angiotensin-aldosterone system blockers associated with improved kidney prognosis in Korean IgA nephropathy patients
DC Field | Value | Language |
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dc.contributor.author | 한승혁 | - |
dc.date.accessioned | 2021-12-28T16:48:34Z | - |
dc.date.available | 2021-12-28T16:48:34Z | - |
dc.date.issued | 2021-07 | - |
dc.identifier.issn | 2048-8505 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/186806 | - |
dc.description.abstract | Background: We aimed to describe the characteristics of immunoglobulin A nephropathy (IgAN) in Korea with assessment for time trends. Methods: We performed a multicenter retrospective observational cohort study including biopsy-confirmed native IgAN cases from four tertiary hospitals in Korea. Time eras of diagnosis were stratified into 1979-2003, 2004-9 and 2010-17. The prognostic variable was progression to end-stage kidney disease (ESKD) analyzed by multivariable Cox regression analysis. Results: We included 1366 (from 1979 to 2003), 1636 (from 2004 to 2009) and 1442 (from 2010 to 2017) IgAN patients in this study. In the recent periods, IgAN had relatively better clinical characteristics, as patients had higher estimated glomerular filtration rates and lower baseline blood pressures than before. The use of renin-angiotensin-aldosterone system (RAAS) blockers increased from 57.7% in 1979-2003 to 80.0% in 2010-17. During a median follow-up duration of 11.3 years, 722 patients progressed to ESKD with an incidence rate of 12.5 per 1000 person-years. The 10-year risk of progression to ESKD was lower in 2010-17 compared with that of 1979-2003 [adjusted hazard ratio 0.692 (95% confidence interval 0.523-0.915)], even after adjustment for multiple clinicopathologic characteristics. The use of RAAS blockers was a significant mediator (P < 0.001) for the association between time trends and lower 10-year ESKD risk. Conclusions: Clinicopathologic characteristics of IgAN in Korea have changed over time. Although the limitation of a retrospective observational study remains, the result showed that the prognosis of IgAN has improved over the study period, possibly related to increased prescription of RAAS blockers. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Oxford University Press | - |
dc.relation.isPartOf | CLINICAL KIDNEY JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Increasing prescription of renin-angiotensin-aldosterone system blockers associated with improved kidney prognosis in Korean IgA nephropathy patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Sehoon Park | - |
dc.contributor.googleauthor | Chung Hee Baek | - |
dc.contributor.googleauthor | Su-Kil Park | - |
dc.contributor.googleauthor | Hee Gyung Kang | - |
dc.contributor.googleauthor | Seung Hyeok Han | - |
dc.contributor.googleauthor | Dong-Ryeol Ryu | - |
dc.contributor.googleauthor | Dong Ki Kim | - |
dc.contributor.googleauthor | Kook-Hwan Oh | - |
dc.contributor.googleauthor | Kwon Wook Joo | - |
dc.contributor.googleauthor | Yon Su Kim | - |
dc.contributor.googleauthor | Kyung Chul Moon | - |
dc.contributor.googleauthor | Ho Jun Chin | - |
dc.contributor.googleauthor | Hajeong Lee | - |
dc.identifier.doi | 10.1093/ckj/sfaa204 | - |
dc.contributor.localId | A04304 | - |
dc.relation.journalcode | J04067 | - |
dc.identifier.eissn | 2048-8513 | - |
dc.identifier.pmid | 34084463 | - |
dc.subject.keyword | IgA nephropathy | - |
dc.subject.keyword | aldosterone receptor blockade | - |
dc.subject.keyword | angiotensin-converting enzyme inhibitor | - |
dc.subject.keyword | end-stage kidney disease | - |
dc.subject.keyword | glomerulonephritis | - |
dc.contributor.alternativeName | Han, Seung Hyeok | - |
dc.contributor.affiliatedAuthor | 한승혁 | - |
dc.citation.volume | 14 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1673 | - |
dc.citation.endPage | 1680 | - |
dc.identifier.bibliographicCitation | CLINICAL KIDNEY JOURNAL, Vol.14(6) : 1673-1680, 2021-07 | - |
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