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Robot-assisted partial nephrectomy for high-complexity tumors (PADUA score ≥10): Perioperative, long-term functional and oncologic outcomes

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dc.contributor.author나군호-
dc.contributor.author이종수-
dc.contributor.author한웅규-
dc.contributor.author나군호-
dc.contributor.author이종수-
dc.contributor.author한웅규-
dc.date.accessioned2021-12-28T16:45:49Z-
dc.date.available2021-12-28T16:45:49Z-
dc.date.issued2021-05-
dc.identifier.issn0919-8172-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/186788-
dc.description.abstractObjectives: To evaluate the safety and efficacy, and long-term functional and oncologic outcomes of robot-assisted partial nephrectomy in high-complexity tumors. Methods: Data of 155 patients with a high-complexity tumor (PADUA score ≥10) were reviewed. Trifecta achievement, intra-, perioperative, functional, and oncologic outcomes were analyzed and compared between patients with increasing complexity. Results: Of the 155 patients, 65 (41.9%) patients had a PADUA score of 10, 55 (35.5%) had a PADUA score of 11, and 35 (22.6%) had a PADUA score of 12-13, respectively. The median (interquartile range) operative time, warm ischemia time and estimated blood loss were 150 min (112-186 min), 26 min (23-32 min) and 250 mL (100-500 mL), respectively. Postoperatively, complications occurred in 25 (16.1%) patients, and positive surgical margins in 15 (10.5%) patients. Trifecta was achieved in 67 (43.2%) patients. At a median follow-up period of 58 months, the median estimated glomerular filtration rate preservation was 87% (78-110), and 12 (7.7%) patients developed new-onset chronic kidney disease. Recurrence-free survival and overall survival rates were 93.6% and 96.7%, respectively. Positive surgical margins were statistically different between the groups of PADUA score 10, 11 and 12-13 (P = 0.017), whereas functional and oncologic outcomes were similar. In multivariate logistic regression analysis, increasing tumor size (odds ratio 1.48, 95% confidence interval 1.21-1.87; P < 0.001) and the American Society of Anesthesiologists score 2/3 (odds ratio 0.48, 95% confidence interval 0.24-0.96; P = 0.041) were independent predictors of trifecta failure. Conclusions: Robot-assisted partial nephrectomy is a safe and effective treatment for high-complexity tumors providing excellent long-term functional and oncologic outcomes.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherBlackwell Science Asia-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF UROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHGlomerular Filtration Rate-
dc.subject.MESHHumans-
dc.subject.MESHKidney Neoplasms* / surgery-
dc.subject.MESHNephrectomy / adverse effects-
dc.subject.MESHPostoperative Complications / epidemiology-
dc.subject.MESHPostoperative Complications / etiology-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRobotic Surgical Procedures* / adverse effects-
dc.subject.MESHRobotics*-
dc.subject.MESHTreatment Outcome-
dc.titleRobot-assisted partial nephrectomy for high-complexity tumors (PADUA score ≥10): Perioperative, long-term functional and oncologic outcomes-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Urology (비뇨의학교실)-
dc.contributor.googleauthorPeriklis Koukourikis-
dc.contributor.googleauthorAli Abdullah Alqahtani-
dc.contributor.googleauthorAhmad Almujalhem-
dc.contributor.googleauthorJongsoo Lee-
dc.contributor.googleauthorWoong Kyu Han-
dc.contributor.googleauthorKoon Ho Rha-
dc.identifier.doi10.1111/iju.14507-
dc.contributor.localIdA01227-
dc.contributor.localIdA05500-
dc.contributor.localIdA04308-
dc.contributor.localIdA01227-
dc.contributor.localIdA05500-
dc.contributor.localIdA04308-
dc.relation.journalcodeJ01169-
dc.identifier.eissn1442-2042-
dc.identifier.pmid33604916-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/10.1111/iju.14507-
dc.subject.keywordPADUA score-
dc.subject.keywordkidney neoplasms-
dc.subject.keywordpartial nephrectomy-
dc.subject.keywordrenal cell cancer-
dc.subject.keywordrobotic surgical procedures-
dc.contributor.alternativeNameRha, Koon Ho-
dc.contributor.affiliatedAuthor나군호-
dc.contributor.affiliatedAuthor이종수-
dc.contributor.affiliatedAuthor한웅규-
dc.contributor.affiliatedAuthor나군호-
dc.contributor.affiliatedAuthor이종수-
dc.contributor.affiliatedAuthor한웅규-
dc.citation.volume28-
dc.citation.number5-
dc.citation.startPage554-
dc.citation.endPage559-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF UROLOGY, Vol.28(5) : 554-559, 2021-05-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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