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Efficacy of Whole-Ventricular Radiotherapy in Patients Undergoing Maximal Tumor Resection for Glioblastomas Involving the Ventricle

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dc.contributor.author강석구-
dc.contributor.author김경환-
dc.contributor.author문주형-
dc.contributor.author변화경-
dc.contributor.author서창옥-
dc.contributor.author유지환-
dc.contributor.author윤홍인-
dc.contributor.author장종희-
dc.contributor.author강석구-
dc.contributor.author김경환-
dc.contributor.author문주형-
dc.contributor.author변화경-
dc.contributor.author서창옥-
dc.contributor.author유지환-
dc.contributor.author윤홍인-
dc.contributor.author장종희-
dc.date.accessioned2021-12-28T16:44:58Z-
dc.date.available2021-12-28T16:44:58Z-
dc.date.issued2021-09-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/186783-
dc.description.abstractBackground and purpose: Patients with glioblastoma (GBM) involving the ventricles are at high risk of ventricle opening during surgery and potential ventricular tumor spread. We evaluated the effectiveness of whole-ventricular radiotherapy (WVRT) in reducing intraventricular seeding in patients with GBM and identified patients who could benefit from this approach. Methods and materials: We retrospectively reviewed the data of 382 patients with GBM who underwent surgical resection and temozolomide-based chemoradiotherapy. Propensity score matching was performed to compensate for imbalances in characteristics between patients who did [WVRT (+); n=59] and did not [WVRT (-); n=323] receive WVRT. Local, outfield, intraventricular, and leptomeningeal failure rates were compared. Results: All patients in the WVRT (+) group had tumor ventricular involvement and ventricle opening during surgery. In the matched cohort, the WVRT (+) group exhibited a significantly lower 2-year intraventricular failure rate than the WVRT (-) group (2.1% vs. 11.8%; P=0.045), with no difference in other outcomes. Recursive partitioning analysis stratified the patients in the WVRT (-) group at higher intraventricular failure risk (2-year survival, 14.2%) due to tumor ventricular involvement, MGMT unmethylation, and ventricle opening. WVRT reduced the intraventricular failure rate only in high-risk patients (0% vs. 14.2%; P=0.054) or those with MGMT-unmethylated GBM in the matched cohort (0% vs. 17.3%; P=0.036). Conclusions: WVRT reduced the intraventricular failure rate in patients with tumor ventricular involvement and ventricle opening during surgery. The MGMT-methylation status may further stratify patients who could benefit from WVRT. Further prospective evaluation of WVRT in GBM is warranted.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherFrontiers Research Foundation-
dc.relation.isPartOfFRONTIERS IN ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEfficacy of Whole-Ventricular Radiotherapy in Patients Undergoing Maximal Tumor Resection for Glioblastomas Involving the Ventricle-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학교실)-
dc.contributor.googleauthorKyung Hwan Kim-
dc.contributor.googleauthorJihwan Yoo-
dc.contributor.googleauthorNalee Kim-
dc.contributor.googleauthorJu Hyung Moon-
dc.contributor.googleauthorHwa Kyung Byun-
dc.contributor.googleauthorSeok-Gu Kang-
dc.contributor.googleauthorJong Hee Chang-
dc.contributor.googleauthorHong In Yoon-
dc.contributor.googleauthorChang-Ok Suh-
dc.identifier.doi10.3389/fonc.2021.736482-
dc.contributor.localIdA00036-
dc.contributor.localIdA05226-
dc.contributor.localIdA01383-
dc.contributor.localIdA05136-
dc.contributor.localIdA01919-
dc.contributor.localIdA05158-
dc.contributor.localIdA04777-
dc.contributor.localIdA03470-
dc.contributor.localIdA00036-
dc.contributor.localIdA05226-
dc.contributor.localIdA01383-
dc.contributor.localIdA05136-
dc.contributor.localIdA01919-
dc.contributor.localIdA05158-
dc.contributor.localIdA04777-
dc.contributor.localIdA03470-
dc.relation.journalcodeJ03512-
dc.identifier.eissn2234-943X-
dc.identifier.pmid34621677-
dc.subject.keywordMGMT-
dc.subject.keywordglioblastoma-
dc.subject.keywordradiotherapy-
dc.subject.keywordtemozolomide-
dc.subject.keywordventricle-
dc.contributor.alternativeNameKang, Seok Gu-
dc.contributor.affiliatedAuthor강석구-
dc.contributor.affiliatedAuthor김경환-
dc.contributor.affiliatedAuthor문주형-
dc.contributor.affiliatedAuthor변화경-
dc.contributor.affiliatedAuthor서창옥-
dc.contributor.affiliatedAuthor유지환-
dc.contributor.affiliatedAuthor윤홍인-
dc.contributor.affiliatedAuthor장종희-
dc.contributor.affiliatedAuthor강석구-
dc.contributor.affiliatedAuthor김경환-
dc.contributor.affiliatedAuthor문주형-
dc.contributor.affiliatedAuthor변화경-
dc.contributor.affiliatedAuthor서창옥-
dc.contributor.affiliatedAuthor유지환-
dc.contributor.affiliatedAuthor윤홍인-
dc.contributor.affiliatedAuthor장종희-
dc.citation.volume11-
dc.citation.startPage736482-
dc.identifier.bibliographicCitationFRONTIERS IN ONCOLOGY, Vol.11 : 736482, 2021-09-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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