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사람 위암세포에서 c-erbB-2 단백발현의 의의

DC Field Value Language
dc.contributor.author박병우-
dc.date.accessioned2021-12-27T17:26:35Z-
dc.date.available2021-12-27T17:26:35Z-
dc.date.issued1995-02-
dc.identifier.issn1226-0053-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/186647-
dc.description.statementOfResponsibilityopen-
dc.publisher대한외과학회-
dc.relation.isPartOfJOURNAL OF THE KOREAN SURGICAL SOCIETY (대한외과학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.title사람 위암세포에서 c-erbB-2 단백발현의 의의-
dc.title.alternativeExpression of c-erbB-2 Protein in Human Gasttic Cancer Cells-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthor이경식-
dc.contributor.googleauthor박병우-
dc.contributor.localIdA01475-
dc.relation.journalcodeJ01893-
dc.subject.keywordC-erbB-2 is one of the most well known oncogenes in human malignant tumors and it is expressed about 8~20% in gastric carcinoma. But there is still controversy about the correlation between the c-erbB-2 overexpression and the prognosis of the gastric carcinoma. So we studied the prognostic value of the c-erbB-2 overexpression by comparing the c-erbB-2 overexpression and known prognostic factors of the gastric carcinoma. With single cell suspensions of normal gastric mucosa, primary gastric cancer tissues and malignant cells from ascites arised from gastric carcinomas, the immunoreactivity to c-erbB-2 protein was examined. The results were as follows-
dc.subject.keyword1) The c-erbB-2 protein was expressed only in cancer cells not in cells from normal mucosa. The expression frequency is significantly higher in metastatic tissues(malignant ascites)than those of primary sites. 2) The c-erbB-2 expression discrepancy between differentiated carcinomas and poorly differentiated carcinomas was not significant but these were significantly higher than that in signet ring cell carcinomas. 3) The c-erbB-2 expression frequency was significantly higher in serosal invasive carcinomas than that in serosal non-invasive carcinomas. 4) The c.erbB-2 expression frequency was significantly higher in tumor sizes of larger than 3 cm in diameter than that of less than 3 cm. 5) There were no statistically significant discrepancy along with the lymph node metastasis and stages, but the more lymph nodes metastasis end the higher stages, the more c-erbB-2 ex.pression was noted. These results suggest that the c-erbB-2 overexpression is associated with aggressive cancer biologic behavior.-
dc.contributor.alternativeNamePark, Byeong Woo-
dc.contributor.affiliatedAuthor박병우-
dc.citation.volume48-
dc.citation.number2-
dc.citation.startPage189-
dc.citation.endPage198-
dc.identifier.bibliographicCitationJournal of the Korean Surgical Society (대한외과학회지), Vol.48(2) : 189-198, 1995-02-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
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