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Electrophysiological evidence for the antinociceptive effect of transcutaneous electrical stimulation on mechanically evoked responsiveness of dorsal horn neurons in neuropathic rats
DC Field | Value | Language |
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dc.contributor.author | 임중우 | - |
dc.date.accessioned | 2021-12-27T17:24:14Z | - |
dc.date.available | 2021-12-27T17:24:14Z | - |
dc.date.issued | 1995-06 | - |
dc.identifier.issn | 0304-3940 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/186615 | - |
dc.description.abstract | Using a rat model of peripheral neuropathy induced by a tight ligation of 5–6 spinal nerves, the effects of transcutaneous electrical stimulation on the mechanical responses of wide dynamic range (WDR) dorsal horn neurons were investigated. The responses of the WDR neurons to both the brush and pinch stimuli were found to be enhanced in the neuropathic rats compared to those in the normal rats. These enhanced responses were depressed by low-frequency and high-intensity transcutaneous electrical stimulation (2 Hz, 4–5 mA) applied to the somatic receptive field. The durations of the depressive effects on the brush responses ranged between 30 and 45 min and those on the pinch responses were 60–90 min. These results imply that the transcutaneous electrical stimulation used here produces an antinociceptive effect via a depressive action on the enhanced mechanical responsiveness of the spinal neurons in this rat model of peripheral neuropathy. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Scientific Publishers Ireland | - |
dc.relation.isPartOf | NEUROSCIENCE LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Electroacupuncture | - |
dc.subject.MESH | Electrophysiology | - |
dc.subject.MESH | Evoked Potentials / physiology* | - |
dc.subject.MESH | Hyperalgesia / physiopathology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mechanoreceptors / physiology* | - |
dc.subject.MESH | Neurons / physiology* | - |
dc.subject.MESH | Pain Management | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Spinal Cord / cytology* | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Transcutaneous Electric Nerve Stimulation* | - |
dc.title | Electrophysiological evidence for the antinociceptive effect of transcutaneous electrical stimulation on mechanically evoked responsiveness of dorsal horn neurons in neuropathic rats | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학교실) | - |
dc.contributor.googleauthor | Joong Woo Leem | - |
dc.contributor.googleauthor | Eun Sun Park | - |
dc.contributor.googleauthor | Kwang Se Paik | - |
dc.identifier.doi | 10.1016/0304-3940(95)11644-C | - |
dc.contributor.localId | A03409 | - |
dc.relation.journalcode | J02364 | - |
dc.identifier.eissn | 1872-7972 | - |
dc.identifier.pmid | 7566649 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/030439409511644C | - |
dc.contributor.alternativeName | Leem, Joong Woo | - |
dc.contributor.affiliatedAuthor | 임중우 | - |
dc.citation.volume | 192 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 197 | - |
dc.citation.endPage | 200 | - |
dc.identifier.bibliographicCitation | NEUROSCIENCE LETTERS, Vol.192(3) : 197-200, 1995-06 | - |
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