Cited 0 times in
Interleukin - 6 가 배양된 정맥내피세포에서 E - selectin 의 표현에 미치는 영향
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김동수 | - |
dc.date.accessioned | 2021-12-27T17:20:30Z | - |
dc.date.available | 2021-12-27T17:20:30Z | - |
dc.date.issued | 1995-06 | - |
dc.identifier.issn | 1225-679X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/186566 | - |
dc.description.abstract | Interleukin-6(IL-6) is a pleomorphic cytokine , which has a variety of functions including stimulatory effect of hepatocytes to produce acute phase reactants . With interleukin - l(IL - 1) and tumor necrosis factor - a( TNF ? A ) , IL-6 has a function in acute inflammation. We conducted this study to clarified that IL-6 also has a function to stimulate the expression of E-selectin on cultured HUVEC like IL-1 and TNF-a. The results were as follows ; l. IL-6 had a stimulatory effect to express E - selectin on HUVEC with dose-dependent pattern. 2. A peak stimulatory effect of IL - 6 on expression of E - selectin was 24 hours after incubation and then decreased gradually. 3. This stimulatory effect of IL - 6 on expression of E-selectin was blocked by mouse anti-IL-6 monoclonal antibody. 4. A stimulatory effect of IL-6 on E-selectin expression could be also observed on FACS analysis. 5. When incubated with IL - 6 for 16 hours , the morphology of HUVEC showed shrunken cells, vacuoles in cytoplasms , and some necrosis which looked like a inflammatory response . | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한 소아알레르기 호흡기학회 | - |
dc.relation.isPartOf | Pediatric Allergy and Respiratory Disease(소아알레르기 호흡기학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Interleukin - 6 가 배양된 정맥내피세포에서 E - selectin 의 표현에 미치는 영향 | - |
dc.title.alternative | Effect of Interleukin - 6 on the Expression of E - selectin on Cultured HUVEC | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | ;Dept. of Pediatrics (소아과학교실) | - |
dc.contributor.googleauthor | 김동수 | - |
dc.contributor.googleauthor | 한부현 | - |
dc.contributor.googleauthor | 이기영 | - |
dc.contributor.localId | A00405 | - |
dc.relation.journalcode | J02476 | - |
dc.contributor.alternativeName | Kim, Dong Soo | - |
dc.contributor.affiliatedAuthor | 김동수 | - |
dc.citation.volume | 5 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 60 | - |
dc.citation.endPage | 69 | - |
dc.identifier.bibliographicCitation | Pediatric Allergy and Respiratory Disease (소아알레르기 호흡기학회지), Vol.5(1) : 60-69, 1995-06 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.