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Fentanyl이 흰쥐 대동맥 평활근의 이완에 미치는 영향
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 곽영란 | - |
dc.contributor.author | 김원옥 | - |
dc.date.accessioned | 2021-12-27T17:19:25Z | - |
dc.date.available | 2021-12-27T17:19:25Z | - |
dc.date.issued | 1995-06 | - |
dc.identifier.issn | 0302-5780 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/186554 | - |
dc.description.abstract | The mechanism of vasodilation induced by fentanyl was investigated using isolated rat thoracic aortic rings. Rings were contracted with norepinephrine(10(-7) M, NE) and potassium chloride(40 mM, KC1) with and without endothelium Fentanyl (10(-9)-10(-5) M) produced dose-dependent relaxation and had no significant effect from endothelium(intact and denuded rings, test with 3X10(-4) M LNAME, N-nitro-L-arginine methyl ester). Pretreatment of indomethacin(2.5X10(-3) M, inhibitor of cyclooxygenase) failed to influence of cumulative dose-response curves. RD(50)(50% relaxation dose) and KC1/NE ratio as potency difference of fentanyl, verapamil(10(-8)-10(-5) M, Ca2+ channel blocker), nitroglycerin(10(-10)-10(-5) M, activator of guanylate cyclase) were not similar. Fentanyl and control(distilled water) were not demonstrated any different contraction produced by incremental addition of Ca2+ to aortic rings exposed to Ca2+ free, K+ -depolarized(100 mM KCl) solution(extracellular Ca2+ influx). But fentanyl had effect on intracellular Ca2+ release elicited by caffeine(20 mM) and NE(10(-7) M) indicated by dose-dependent inhibition of contraction in Ca2+ free solution. We conclude that, in rat aorta, fentanyl-induced relaxation is endothelium-independent but mediated by inhibition of alpha-adrenoceptors operated intracellular Ca2+ release (inhibition of contraction by NE) and caffeine-induced Ca2+ release from store. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한마취과학회 | - |
dc.relation.isPartOf | Journal of Korean Society of Anesthesiologist(대한마취과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Fentanyl이 흰쥐 대동맥 평활근의 이완에 미치는 영향 | - |
dc.title.alternative | Effects of Fentanyl on Relaxation in Smooth Muscle of the Rat Aorta | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) | - |
dc.contributor.googleauthor | 김원옥 | - |
dc.contributor.googleauthor | 길혜금 | - |
dc.contributor.googleauthor | 곽영란 | - |
dc.contributor.googleauthor | 이근욱 | - |
dc.identifier.doi | 10.4097/kjae.1995.28.6.739 | - |
dc.contributor.localId | A00172 | - |
dc.contributor.localId | A00766 | - |
dc.relation.journalcode | J01540 | - |
dc.subject.keyword | Fentanyl | - |
dc.subject.keyword | Ca2+ | - |
dc.subject.keyword | Endothelium | - |
dc.subject.keyword | Intracelluar Ca2+ store | - |
dc.contributor.alternativeName | Kwak, Young Lan | - |
dc.contributor.affiliatedAuthor | 곽영란 | - |
dc.contributor.affiliatedAuthor | 김원옥 | - |
dc.citation.volume | 28 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 739 | - |
dc.citation.endPage | 746 | - |
dc.identifier.bibliographicCitation | Journal of Korean Society of Anesthesiologist (대한마취과학회지), Vol.28(6) : 739-746, 1995-06 | - |
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