종합병원 환자에서 분리된 호기성 그람음성간균의 cefepime에 대한 감수성

Abstract

Background : Previous agar dilution test showed that cefepime is very active against various gram-nagative bacilli including the third generation cephalosporin-resistant Enter-obacter, Serratia and Citrobacter. The aim of this study was to test the susceptibility of large number of recent clinical isolates of gram-negative bacilli to cefepime. Methods : A total of 4797 isolates of Enterobacteriaceae, Aeromonas, Pseudomonas aeruginosa, Acinetobacter baumannii and Xanthomonas maltophilia isolated from a tertiary-care general hospital patients, were tested by the NCCLS disk kiffusion test and the results were analyzed using a WHONET III program. Results : Resistance rates of Enterobacteriaceae were 82% to ampicillin, 71% to cephalothin, 24% to gentamicin, 10% to ofloxacin, 15 to cefotaxime, 7% to cefoperazone/sulbactam and 1% to cefepime. P. aeruginosa showed the lowest resistance rate of 24% to both cefepime and ceftazidime. The cefepime susceptible rates of cefotaxime-resistant isolates were C. freundii 77%, E. cloacae 61% and S. marcescens 53%. Conclusion : Resistance rates of the recent clinical isolates of aerobic gram-negative bacilli, including the third generation cephalosporin-resistant nosocomial pathogens, are lower to cefepime than to the other antimicrobial agents compared.