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Cyproheptadine Angmentation of Haloperidol in Chronic Schizophrenic Patients : A Double Blind Placebo-Controlled Study

Authors
 H.S. Lee  ;  D.H. Song  ;  J.H. Kim  ;  Y.M. Lee  ;  E.S. Han  ;  K.J. Yoo 
Citation
 INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, Vol.10(2) : 67-72, 1995-06 
Journal Title
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
ISSN
 0268-1315 
Issue Date
1995-06
MeSH
Adult ; Chronic Disease ; Cyproheptadine / therapeutic use* ; Double-Blind Method ; Drug Therapy, Combination ; Female ; Follow-Up Studies ; Haloperidol / therapeutic use* ; Humans ; Hydrocortisone / blood ; Male ; Placebos ; Prolactin / blood ; Schizophrenia / blood ; Schizophrenia / drug therapy* ; Time Factors
Abstract
A 6 week double-blind placebo-controlled trial of cyproheptadine augmentation of ongoing haloperidol treatment was conducted in 40 chronic schizophrenic in-patients. Cyproheptadine augmentation, compared to administration of haloperidol with placebo, did not produce a statistically significant improvement in psychotic symptoms. Cyproheptadine augmentation caused significant reduction in the extrapyramidal symptoms, which supports the atypical profile of antipsychotics. As to the neuroendocrinological effect, cyproheptadine augmentation did not reduce the plasma prolactin level but did induce a decrease in the plasma cortisol level. Although long-term follow-up studies are needed to confirm the results, this study suggests that cyproheptadine augmentation may be effective in treating chronic schizophrenic patients who are intolerant of extrapyramidal side effects of conventional antipsychotics.
Full Text
https://oce.ovid.com/article/00004850-199506000-00002/HTML
DOI
10.1097/00004850-199506000-00002
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Song, Dong Ho(송동호) ORCID logo https://orcid.org/0000-0002-9647-3130
Lee, Hong Shick(이홍식)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/186533
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