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Effects of dexamethasone on laryngeal edema following short-term intubation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 고신옥 | - |
dc.contributor.author | 길혜금 | - |
dc.contributor.author | 김원옥 | - |
dc.date.accessioned | 2021-12-27T17:14:20Z | - |
dc.date.available | 2021-12-27T17:14:20Z | - |
dc.date.issued | 1995-12 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/186490 | - |
dc.description.abstract | Following short-term intubation for general anesthesia, respiratory difficulty may result from laryngeal or subglottic edema after extubation. We have hypothesized that this problem could be pretreated by administering a high-dose of dexamethasone intravenously before extubation. After glottic injuries were made under direct laryngoscopic view, intubation was performed and maintained for 1 hour in 33 rabbits. The rabbits were divided into 3 groups; dexamethasone (1 mg/kg) was administered to group 1(n=12) immediately after intubation and group 2(n=10) just before extubation; group 3(n=11) received normal saline, just before extubation. After extubation, subglottic excursion pressure was measured for 4 hours. 15 injured rabbit larynges and 3 normal ones were extracted for histologic section. 2 of 12 rabbits in group 1; 3 of 10 in group 2; and 5 of 11 in group 3, showed mild stridor after extubation(p>0.05). All rabbits developed maximum increase in subglottic pressure within 2 hours after extubation. Group 1 and 2 showed less increase in pressure compared to group 3(p<0.05), but here was no statistical difference between group 1 and 2(p>0.05). Histologic sections of the larynges showed less submucosal edema, including other changes in group 1 and 2, than in group 3(p<0.05). In conclusion, administering a high-dose of dexamethasone before extubation, is effective in prophylaxis and treatment of laryngeal injuries following short-term intubation in rabbits. This is especially true in edema. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Dexamethasone / administration & dosage | - |
dc.subject.MESH | Dexamethasone / therapeutic use* | - |
dc.subject.MESH | Intubation, Intratracheal / adverse effects* | - |
dc.subject.MESH | Laryngeal Edema / etiology | - |
dc.subject.MESH | Laryngeal Edema / prevention & control* | - |
dc.subject.MESH | Rabbits | - |
dc.title | Effects of dexamethasone on laryngeal edema following short-term intubation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) | - |
dc.contributor.googleauthor | Hae Keum Kil | - |
dc.contributor.googleauthor | Won Oak Kim | - |
dc.contributor.googleauthor | Shin Ok Koh | - |
dc.identifier.doi | 10.3349/ymj.1995.36.6.515 | - |
dc.contributor.localId | A00126 | - |
dc.contributor.localId | A00283 | - |
dc.contributor.localId | A00766 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 8599253 | - |
dc.subject.keyword | Acute laryngeal edema | - |
dc.subject.keyword | intubation | - |
dc.subject.keyword | dexamethasone | - |
dc.subject.keyword | rabbit | - |
dc.contributor.alternativeName | Koh, Shin Ok | - |
dc.contributor.affiliatedAuthor | 고신옥 | - |
dc.contributor.affiliatedAuthor | 길혜금 | - |
dc.contributor.affiliatedAuthor | 김원옥 | - |
dc.citation.volume | 36 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 515 | - |
dc.citation.endPage | 520 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.36(6) : 515-520, 1995-12 | - |
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