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소아 및 청소년기의 뇌하수체선종
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최중언 | - |
dc.date.accessioned | 2021-12-27T17:07:24Z | - |
dc.date.available | 2021-12-27T17:07:24Z | - |
dc.date.issued | 1995-08 | - |
dc.identifier.issn | 1225-8245 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/186400 | - |
dc.description.abstract | Between 1989 and 1993, 13 patients with pituitary adenoma underwent operation/radiosurgery at Yonsei University Hospital before their 18th birthday. This comprises an incidence of 5.3%(13/247) of all pituitary adenoma patients who were treated at our institution during the study period. There were 7 boys and 6 girls ranging in age from 10.6 to 17.9 years(average, 14.9 years). The mean follow-up period was 22.4 months(7-55 months). Immunohistochemical study revealed 4 prolactin(PRL)-secreting, 3 growth hormone(GH)-secreting(PRL was also positive in one), 1 adrenocortical hormone(ACTH)-secreting, 1 thyroid stimulating hormone(TSH)-secreting, and 4 non-functioning adenomas. Nine of 13 patients(77%) presented with symptomatic endocrinopathy due to hormonal hypersecretion and/or delay in linear growth or onset of puberty. Microadenomas comprised one of nine functionng adenomas, and one of 4 nonfunctioning adenomas, or 15% overall. In 10 patients(77%), at least one pituitary hormonal axis was abnormal. Transsphenoidal and transcranial resections were employed in 8 and 4 patients, respectively. One patient with nonfunctioning microadenoma underwent gamma knife radiosurgery. Endoclinologically successful treatment was possible in 4 of 9 functioning adenomas(44%). Gross total resections confirmed by follow-up study were achieved in 2 of 3 nonfunctioning adenomas. One nonfunctioning microadenoma treated by radiosurgery showed no progression on follow-up study 20 months after radiosurgery. Seven patients(54%) were treated successfully with either operation or radiosurgery. Adjuvant therapy was applied to 5 patients. Overall tumor control was achieved in 91%. Long-term partial or full hormone replacement was necessary in 69%. It is concluded that early diagnosis, vigorous approach to complete cure, and more strict endocrinological management for sexual maturation and growth are mandatory in the management of pediatric pituitary adenomas. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한신경외과학회 | - |
dc.relation.isPartOf | Journal of Korean Neurosurgical Society(대한신경외과학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 소아 및 청소년기의 뇌하수체선종 | - |
dc.title.alternative | Pituitary Adenomas in Childhood and Adolescence | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학교실) | - |
dc.contributor.googleauthor | 김은영 | - |
dc.contributor.googleauthor | 최중언 | - |
dc.contributor.googleauthor | 정상섭 | - |
dc.contributor.googleauthor | 이규창 | - |
dc.contributor.googleauthor | 김덕희 | - |
dc.contributor.localId | A04194 | - |
dc.relation.journalcode | J01521 | - |
dc.subject.keyword | Pituitary adenoma | - |
dc.subject.keyword | Adolescence | - |
dc.subject.keyword | Transsphenoidal approach | - |
dc.subject.keyword | Radiosurgery | - |
dc.contributor.alternativeName | Choi, Joong Uhn | - |
dc.contributor.affiliatedAuthor | 최중언 | - |
dc.citation.volume | 24 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 864 | - |
dc.citation.endPage | 875 | - |
dc.identifier.bibliographicCitation | Journal of Korean Neurosurgical Society (대한신경외과학회지), Vol.24(8) : 864-875, 1995-08 | - |
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