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소아 및 청소년기의 뇌하수체선종

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dc.contributor.author최중언-
dc.date.accessioned2021-12-27T17:07:24Z-
dc.date.available2021-12-27T17:07:24Z-
dc.date.issued1995-08-
dc.identifier.issn1225-8245-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/186400-
dc.description.abstractBetween 1989 and 1993, 13 patients with pituitary adenoma underwent operation/radiosurgery at Yonsei University Hospital before their 18th birthday. This comprises an incidence of 5.3%(13/247) of all pituitary adenoma patients who were treated at our institution during the study period. There were 7 boys and 6 girls ranging in age from 10.6 to 17.9 years(average, 14.9 years). The mean follow-up period was 22.4 months(7-55 months). Immunohistochemical study revealed 4 prolactin(PRL)-secreting, 3 growth hormone(GH)-secreting(PRL was also positive in one), 1 adrenocortical hormone(ACTH)-secreting, 1 thyroid stimulating hormone(TSH)-secreting, and 4 non-functioning adenomas. Nine of 13 patients(77%) presented with symptomatic endocrinopathy due to hormonal hypersecretion and/or delay in linear growth or onset of puberty. Microadenomas comprised one of nine functionng adenomas, and one of 4 nonfunctioning adenomas, or 15% overall. In 10 patients(77%), at least one pituitary hormonal axis was abnormal. Transsphenoidal and transcranial resections were employed in 8 and 4 patients, respectively. One patient with nonfunctioning microadenoma underwent gamma knife radiosurgery. Endoclinologically successful treatment was possible in 4 of 9 functioning adenomas(44%). Gross total resections confirmed by follow-up study were achieved in 2 of 3 nonfunctioning adenomas. One nonfunctioning microadenoma treated by radiosurgery showed no progression on follow-up study 20 months after radiosurgery. Seven patients(54%) were treated successfully with either operation or radiosurgery. Adjuvant therapy was applied to 5 patients. Overall tumor control was achieved in 91%. Long-term partial or full hormone replacement was necessary in 69%. It is concluded that early diagnosis, vigorous approach to complete cure, and more strict endocrinological management for sexual maturation and growth are mandatory in the management of pediatric pituitary adenomas.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisher대한신경외과학회-
dc.relation.isPartOfJournal of Korean Neurosurgical Society(대한신경외과학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.title소아 및 청소년기의 뇌하수체선종-
dc.title.alternativePituitary Adenomas in Childhood and Adolescence-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학교실)-
dc.contributor.googleauthor김은영-
dc.contributor.googleauthor최중언-
dc.contributor.googleauthor정상섭-
dc.contributor.googleauthor이규창-
dc.contributor.googleauthor김덕희-
dc.contributor.localIdA04194-
dc.relation.journalcodeJ01521-
dc.subject.keywordPituitary adenoma-
dc.subject.keywordAdolescence-
dc.subject.keywordTranssphenoidal approach-
dc.subject.keywordRadiosurgery-
dc.contributor.alternativeNameChoi, Joong Uhn-
dc.contributor.affiliatedAuthor최중언-
dc.citation.volume24-
dc.citation.number8-
dc.citation.startPage864-
dc.citation.endPage875-
dc.identifier.bibliographicCitationJournal of Korean Neurosurgical Society (대한신경외과학회지), Vol.24(8) : 864-875, 1995-08-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers

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