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Tumor Necrosis Factor-α가 배양된 돼지갑상선세포에서의 갑상선글로불린 생산과 TSH작용에 미치는 영향
DC Field | Value | Language |
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dc.contributor.author | 이현철 | - |
dc.date.accessioned | 2021-12-27T16:53:28Z | - |
dc.date.available | 2021-12-27T16:53:28Z | - |
dc.date.issued | 1995-09 | - |
dc.identifier.issn | 1015-6380 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/186226 | - |
dc.description.abstract | Abnormal thyroid function is seen in a wide variety of patients with acute and chronic nonthyroidal-illness, consisting of reduction in both thyroid function and peripheral T_4 to T_3 conversion including decreased serum thyroxin(T_4), decreased triiodothyronine and normal or slightly increased serum TSH. Recently increasing awareness of the role of tumor necrosis factor-alpha(TNF-alpha) in systemic illness led us to consider a possible contribution of TNF-alpha to thyroid dysfunction in this setting. So we hypothesized that TNF-alpha might affect the function of the thyroid gland. We, therefore, explored the effects of TNF-alpha on the cultured porcine thyroid cells in TSH-stimulated and TSH-nonstimulated conditions. Primarily cultured porcine thyroid cells were incubated with various concentrations(-500pg/ml) of recombinant buman TNF-alpha and bTSH(1mu/ml), with measurement of secreted thyroglobulin(Tg) and cyclic AMP(c-AMP) as the end points of stimulation, and produced intracellular Tg by pulse-labelling. TNF-alpha significantly inhibited TSH-stimulated intracellular Tg synthesis and extracellar Tg secretion at 200 and 500pg/ml concentration. TNF-alpha didn't affect c-AMP production at any concentration tested. So we conclude that increased in serum TNF-alpha may be responsible for reduced thyroid function in patients with acute and chronic nonthyroidal-illness | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한내분비학회 | - |
dc.relation.isPartOf | Journal of Korea Society of Endocrinology(대한내분비학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Tumor Necrosis Factor-α가 배양된 돼지갑상선세포에서의 갑상선글로불린 생산과 TSH작용에 미치는 영향 | - |
dc.title.alternative | The Effect of Tumor Necrosis Fator-α on the Thyroglobulin Synthesis and TSH Action in Cultured Porcine Thyroid Cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | 김경래 | - |
dc.contributor.googleauthor | 이은직 | - |
dc.contributor.googleauthor | 조재화 | - |
dc.contributor.googleauthor | 남문석 | - |
dc.contributor.googleauthor | 남수연 | - |
dc.contributor.googleauthor | 송영득 | - |
dc.contributor.googleauthor | 임승길 | - |
dc.contributor.localId | A03301 | - |
dc.relation.journalcode | J01478 | - |
dc.subject.keyword | Thyroglobulin synthesis | - |
dc.subject.keyword | TNF - alpha | - |
dc.contributor.alternativeName | Lee, Hyun Chul | - |
dc.contributor.affiliatedAuthor | 이현철 | - |
dc.citation.volume | 10 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 220 | - |
dc.citation.endPage | 228 | - |
dc.identifier.bibliographicCitation | Journal of Korea Society of Endocrinology (대한내분비학회지), Vol.10(3) : 220-228, 1995-09 | - |
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