Patients with wound infection and cutaneous bacterial infection were enrolled in a study of oral] administered ecfpodoxime proxetil : 20 patients with infection received cefpodoxime proxetil 100 to 200mg twice daily for 6-9 days. 17 of 20(85.0%) evaluable patients were clinically cured post--therapy, the remainder being classified as marked improvement and moderate improvement. The pathogen eradication rate at the end of therapy was 9 of 9(100%). There was no significant a drug related adverse reaction. Cefpodoxime proxetil appears to be useful and safe agent in the therapy of skin infections.