신장이식술시 마취유도제로서 Propofol의 심혈관계 효과

Abstract

A need has been recognized for a safe and effective induction for patients undergoing elective renal transplantations. We have evaluated the effect of propofol (injection rate; 50 mg/min, average dosage; 2.28+/-0.08 mg/kg, n=10) on a cardiovascular stability compared with that of thiopental (injection rate; 100 mg/min, average dosage; 5.22+/-0.18 mg/kg, n=10) as an induction agent. Blood pressure and heart rate as cardiovascular parameters were checked before induction(control), one, two, three minutes after induction, before and after orotracheal spray of lidocaine, and immediately, one and two minutes after endotracheal intubation. The results were as follows: 1) There were no significant cardiovascular changes in the propofol group during the whole induction period. 2) In the thiopental group, diastolic blood pressures checked just after intubation, which were 120.20+/-7.79 mmHg, were significantly higher than those of one or two minutes after induction, which were 86.30+/-4.36, 88.40+/-3.85 mmHg, respectively. The above results suggest that intravenous propofol (2.0~2.5 mg/kg) is a safe and effective induction agent for renal recipients.