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DNA복제이상이 있는 대장암의 병리학적 특성
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김호근 | - |
dc.contributor.author | 박찬일 | - |
dc.date.accessioned | 2021-12-27T16:49:22Z | - |
dc.date.available | 2021-12-27T16:49:22Z | - |
dc.date.issued | 1995-10 | - |
dc.identifier.issn | 0379-1149 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/186170 | - |
dc.description.abstract | Unstable microsatellite repeat sequences or DNA replication errors(RER) due to defective mismatch repair genes have been reported in a subset of sporadic colorectal tumors and in most tumors of patients of hereditary nonpolyposis colorectal carcinoma(HNPCC). To elucidate the clinicopathological correlation of these RER-positive cancers, we examined 16 cases of colorectal carcinoma of different histologic subtypes(6 cases of carcinoma with no gland formation, 5 cases of mucinous carcinoma and 5 cases of gland forming carcinoma). We detected RER .in five cases. The patients with RER-positive cancers had a marked preponderance of carcinoma with no gland formation(4 out of 6 carcinomas with no gland formation were RER-positive cancers) and of cancers proximal to splenic flexure(all of the RER-positive cases were proximal colon carcinomas). We conclude that RER-positive cancers have unique pathologic features that may be useful for the screening and counselling of patients with hereditary colon cancers. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한병리학회 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF PATHOLOGY (대한병리학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | DNA복제이상이 있는 대장암의 병리학적 특성 | - |
dc.title.alternative | Pathologic Characteristics of Colorectal Cancers with DNA Replication Errors | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | 김호근 | - |
dc.contributor.googleauthor | 진윤미 | - |
dc.contributor.googleauthor | 심정연 | - |
dc.contributor.googleauthor | 박찬일 | - |
dc.contributor.localId | A01183 | - |
dc.contributor.localId | A01710 | - |
dc.relation.journalcode | J02093 | - |
dc.subject.keyword | DNA replication errors | - |
dc.subject.keyword | Colon cancer | - |
dc.contributor.alternativeName | Kim, Hogeun | - |
dc.contributor.affiliatedAuthor | 김호근 | - |
dc.contributor.affiliatedAuthor | 박찬일 | - |
dc.citation.volume | 29 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 590 | - |
dc.citation.endPage | 595 | - |
dc.identifier.bibliographicCitation | Korean Journal of Pathology (대한병리학회지), Vol.29(5) : 590-595, 1995-10 | - |
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