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Analysis of nm23 expression as a prognostic parameter in renal cell carcinoma
DC Field | Value | Language |
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dc.contributor.author | 조남훈 | - |
dc.date.accessioned | 2021-12-27T16:47:59Z | - |
dc.date.available | 2021-12-27T16:47:59Z | - |
dc.date.issued | 1995-08 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/186153 | - |
dc.description.abstract | To identify the clinicopathological events including nm23 expression that underlies progression in renal cell carcinoma, a retrospective analysis of patients with renal cell carcinoma was performed. Ninety-eight cases of radical nephrectomies with extensive regional or para-aortic lymph node dissection were assessed for clinicopathological variables, and eighty-five cases underwent nm23/NDPK-A protein immunohistochemical staining. Significant parameters in survival were tumor size, histologic pattern, Fuhrman's nuclear grade, pathologic T(pT) stage, pathologic N stage, M stage, tumor thrombi, location of metastasis, and nm23 staining intensity. To assess the relationship with survival, the tumors with low and high nm23 expressions were compared. The fifty-nine patients with a high staining intensity had a significantly worse survival than did the twenty-six with a low staining intensity (p = 0.0015). Additionally nm23 staining intensity was correlated with tumor size, Fuhrman's nuclear grade, pT, and distant metastasis. Therefore, the immunostaining intensity of nm23 protein could be used as a prognostic parameter with an inverse correlation. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | 대한의학회(The Korean Academy of Medical Sciences) | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Carcinoma, Renal Cell / enzymology* | - |
dc.subject.MESH | Carcinoma, Renal Cell / mortality | - |
dc.subject.MESH | Carcinoma, Renal Cell / pathology | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kidney Neoplasms / enzymology* | - |
dc.subject.MESH | Kidney Neoplasms / mortality | - |
dc.subject.MESH | Kidney Neoplasms / pathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Monomeric GTP-Binding Proteins* | - |
dc.subject.MESH | NM23 Nucleoside Diphosphate Kinases | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Nucleoside-Diphosphate Kinase / analysis* | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Transcription Factors / analysis* | - |
dc.title | Analysis of nm23 expression as a prognostic parameter in renal cell carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Dong Soo Park | - |
dc.contributor.googleauthor | Nam Hoon Cho | - |
dc.contributor.googleauthor | Young Tae Lee | - |
dc.contributor.googleauthor | Chanil Park | - |
dc.contributor.googleauthor | Jin Moo Lee | - |
dc.identifier.doi | 10.3346/jkms.1995.10.4.258 | - |
dc.contributor.localId | A03812 | - |
dc.relation.journalcode | J01517 | - |
dc.identifier.eissn | 1598-6357 | - |
dc.identifier.pmid | 8593205 | - |
dc.contributor.alternativeName | Cho, Nam Hoon | - |
dc.contributor.affiliatedAuthor | 조남훈 | - |
dc.citation.volume | 10 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 258 | - |
dc.citation.endPage | 262 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.10(4) : 258-262, 1995-08 | - |
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