Cited 0 times in
중합효소연쇄반응법에 의한 B형 간염바이러스 DNA 검출과 혈청학적 지표의 비교 검토
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김현숙 | - |
dc.contributor.author | 송경순 | - |
dc.contributor.author | 이경아 | - |
dc.date.accessioned | 2021-12-27T16:41:02Z | - |
dc.date.available | 2021-12-27T16:41:02Z | - |
dc.date.issued | 1995-02 | - |
dc.identifier.issn | 1015-6445 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/186056 | - |
dc.description.abstract | Background : Serologic assays for the detection of markers for hepatitis B viral infection have been used routinely in the clinical laboratories since the early 1970\'s. Negative results with these tests delineate classically a group of viral hepatitis defined as non-A, non-B hepatitis. However, some observations suggest that this group might include HBV or HBV-related viruses. We thus compared the results of Polymerase Chain Reaction(PCR) for the detection of hepatitis B virus DNA(HBV-DNA) with the status of serologic markers. Methods : We analyzed the data from 118 patients referred for the evaluation of serologic markers and HBV-DNA by PCR, over a period from April, 1991 to March, 1994. Serologic markers including HBsAg, HBsAb, HBcAb, HBeAg, and HBeAb were performed with the method of enzyme-linked immunosorbent assay. Results : Serum HBV-DNA by PCR was detected in 77% of HBsAg-positive cases as well as in 20% of HBsAg-negative patients. Not only the most patients(91%) with HBsAg and HBeAg positivity, but also, some HBsAg-positive patients(47%) with seroconversion(HBeAg negative and HBeAb-positive) were found to have HBV-DNA. In 6 cases with positivity only for HBcAb, 2 cases(33%) were found to have HBV-DNA. There was no significant correlation between ALT levels and HBVPCR results among 125 HBsAg-positive cases (P>0.1). Conclusion : The PCR assay seems to be potentially a valuable diagnostic tool for the evaluation of variable serologic status and may help to assess the condition of patients related with HBV infection. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한임상병리학회 | - |
dc.relation.isPartOf | Korean Journal of Clinical Pathology(대한임상병리학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 중합효소연쇄반응법에 의한 B형 간염바이러스 DNA 검출과 혈청학적 지표의 비교 검토 | - |
dc.title.alternative | Comparison of the Polymerase Chain Reaction and Serologic Assay for the Detection of Hepatitis B Virus | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | 이경아 | - |
dc.contributor.googleauthor | 정종신 | - |
dc.contributor.googleauthor | 이창훈 | - |
dc.contributor.googleauthor | 김현숙 | - |
dc.contributor.googleauthor | 송경순 | - |
dc.contributor.localId | A01117 | - |
dc.contributor.localId | A02011 | - |
dc.contributor.localId | A02647 | - |
dc.relation.journalcode | J01988 | - |
dc.contributor.alternativeName | Kim, Hyon Suk | - |
dc.contributor.affiliatedAuthor | 김현숙 | - |
dc.contributor.affiliatedAuthor | 송경순 | - |
dc.contributor.affiliatedAuthor | 이경아 | - |
dc.citation.volume | 15 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 132 | - |
dc.citation.endPage | 138 | - |
dc.identifier.bibliographicCitation | Korean Journal of Clinical Pathology (대한임상병리학회지), Vol.15(1) : 132-138, 1995-02 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.