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Value of Area Postrema Syndrome in Differentiating Adults With AQP4 vs. MOG Antibodies

Authors
 Jae-Won Hyun  ;  Young Nam Kwon  ;  Sung-Min Kim  ;  Hye Lim Lee  ;  Woo Kyo Jeong  ;  Hye Jung Lee  ;  Byoung Joon Kim  ;  Seung Woo Kim  ;  Ha Young Shin  ;  Hyun-June Shin  ;  Sun-Young Oh  ;  So-Young Huh  ;  Woojun Kim  ;  Min Su Park  ;  Jeeyoung Oh  ;  Hyunmin Jang  ;  Na Young Park  ;  Min Young Lee  ;  Su-Hyun Kim  ;  Ho Jin Kim 
Citation
 FRONTIERS IN NEUROLOGY, Vol.11 : 396, 2021-06 
Journal Title
FRONTIERS IN NEUROLOGY
Issue Date
2021-06
Keywords
MOG antibody ; aquaporin-4 antibody ; area postrema syndrome ; diagnosis ; neuromyelitis optica spectrum disorder
Abstract
Objectives: To compare the frequency of area postrema syndrome (APS) in adults with anti-aquaporin-4 (AQP4) and anti-myelin oligodendrocyte glycoprotein (MOG) antibodies. Methods: APS is defined as acute or subacute, single or combined, episodic or constant nausea, vomiting, or hiccups, persisting for at least 48 h, which cannot be attributed to any other etiology. The presence of APS was investigated in 274 adults with AQP4 antibodies and 107 adults with MOG antibodies from 10 hospitals. Results: The study population comprised Korean adults (≥18 years). At the time of disease onset, 14.9% (41/274) adults with AQP4 antibodies had APS, while none of the participants with MOG antibodies developed APS (p < 0.001). During the course of the disease, 17.2% (47/274) adults with AQP4 antibodies had APS in contrast to 1.9% (2/107) adults with MOG antibodies with APS (p < 0.001). Conclusions: APS, one of the core clinical characteristics of individuals with AQP4 antibodies, is an extremely rare manifestation in Korean adults with MOG antibodies.
Files in This Item:
T202103535.pdf Download
DOI
10.3389/fneur.2020.00396
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Woo(김승우) ORCID logo https://orcid.org/0000-0002-5621-0811
Shin, Ha Young(신하영) ORCID logo https://orcid.org/0000-0002-4408-8265
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/185989
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