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Intraoperative radiation therapy induces immune response activity after pancreatic surgery

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dc.date.accessioned2021-11-19T01:41:00Z-
dc.date.available2021-11-19T01:41:00Z-
dc.date.issued2021-10-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/185979-
dc.description.abstractBackground: Pancreatic cancer has highly aggressive features, such as local recurrence that leads to significantly high morbidity and mortality and recurrence after successful tumour resection. Intraoperative radiation therapy (IORT), which delivers targeted radiation to a tumour bed, is known to reduce local recurrence by directly killing tumour cells and modifying the tumour microenvironment. Methods: Among 30 patients diagnosed with pancreatic cancer, 17 patients received IORT immediately after surgical resection. We investigated changes in the immune response induced by IORT by analysing the peritoneal fluid (PF) and blood of patients with and without IORT treatment after pancreatic cancer surgery. Further, we treated three pancreatic cell lines with PF to observe proliferation and activity changes. Results: Levels of cytokines involved in the PI3K/SMAD pathway were increased in the PF of IORT-treated patients. Moreover, IORT-treated PF inhibited the growth, migration, and invasiveness of pancreatic cancer cells. Changes in lymphocyte populations in the blood of IORT-treated patients indicated an increased immune response. Conclusions: Based on the characterisation and quantification of immune cells in the blood and cytokine levels in the PF, we conclude that IORT induced an anti-tumour effect by activating the immune response, which may prevent pancreatic cancer recurrence. Clinical trial registration: NCT03273374 .-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherBioMed Central-
dc.relation.isPartOfBMC CANCER-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleIntraoperative radiation therapy induces immune response activity after pancreatic surgery-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorYun Sun Lee-
dc.contributor.googleauthorHyung Sun Kim-
dc.contributor.googleauthorYeona Cho-
dc.contributor.googleauthorIk Jae Lee-
dc.contributor.googleauthorHyo Jung Kim-
dc.contributor.googleauthorDa Eun Lee-
dc.contributor.googleauthorHyeon Woong Kang-
dc.contributor.googleauthorJoon Seong Park-
dc.identifier.doi10.1186/s12885-021-08807-3-
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dc.relation.journalcodeJ00351-
dc.identifier.eissn1471-2407-
dc.identifier.pmid34641806-
dc.subject.keywordCytokine-
dc.subject.keywordImmune response-
dc.subject.keywordIntraoperative radiation therapy-
dc.subject.keywordPancreatic cancer-
dc.contributor.alternativeNameKim, Hyung Sun-
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dc.citation.volume21-
dc.citation.number1-
dc.citation.startPage1097-
dc.identifier.bibliographicCitationBMC CANCER, Vol.21(1) : 1097, 2021-10-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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