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Soluble IL-2R Levels Predict in-Hospital Mortality in COVID-19 Patients with Respiratory Failure

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dc.contributor.author강영애-
dc.contributor.author김영삼-
dc.contributor.author박무석-
dc.contributor.author안진영-
dc.contributor.author이수환-
dc.contributor.author임아영-
dc.contributor.author장혜진-
dc.contributor.author정경수-
dc.contributor.author정지예-
dc.date.accessioned2021-11-19T01:40:45Z-
dc.date.available2021-11-19T01:40:45Z-
dc.date.issued2021-09-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/185978-
dc.description.abstractAcute respiratory distress syndrome is the primary cause of death in patients with coronavirus disease 2019 (COVID-19) pneumonia. Our study aims to determine the association between serum markers and mortality in COVID-19 patients with respiratory failure. This retrospective study was conducted in a tertiary care hospital in South Korea. Forty-nine patients with COVID-19, who required high flow nasal cannulation or mechanical ventilation from February 2020 to April 2021, were included. Demographic and laboratory data were analyzed at baseline and on Day 7 of admission. We found that serum creatinine, troponin, procalcitonin, and soluble interleukin-2 receptor (sIL-2R) at baseline were more elevated in the non-survivor group, but were not associated with mechanical ventilator use on Day 7. Older age, PaO2/FiO2 ratio, lymphocyte and platelet counts, lactate dehydrogenase, IL-6, C-reactive protein, and sIL-2R on Day 7 were significantly associated with mortality. Delta sIL-2R (Day 7-Day 0) per standard deviation was significantly higher in the non-survivor group (adjusted hazard ratio 3.225, 95% confidence interval (CI) 1.151-9.037, p = 0.026). Therefore, sIL-2R could predict mortality in COVID-19 patients with respiratory failure. Its sustained elevation suggests a hyper-inflammatory state, and mirrors the severity of COVID-19 in patients with respiratory failure, thereby warranting further attention.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI AG-
dc.relation.isPartOfJOURNAL OF CLINICAL MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleSoluble IL-2R Levels Predict in-Hospital Mortality in COVID-19 Patients with Respiratory Failure-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorHye Jin Jang-
dc.contributor.googleauthorAh Young Leem-
dc.contributor.googleauthorKyung Soo Chung-
dc.contributor.googleauthorJin Young Ahn-
dc.contributor.googleauthorJi Ye Jung-
dc.contributor.googleauthorYoung Ae Kang-
dc.contributor.googleauthorMoo Suk Park-
dc.contributor.googleauthorYoung Sam Kim-
dc.contributor.googleauthorSu Hwan Lee-
dc.identifier.doi10.3390/jcm10184242-
dc.contributor.localIdA00057-
dc.contributor.localIdA00707-
dc.contributor.localIdA01457-
dc.contributor.localIdA02267-
dc.contributor.localIdA02904-
dc.contributor.localIdA03382-
dc.contributor.localIdA06082-
dc.contributor.localIdA03570-
dc.contributor.localIdA03735-
dc.relation.journalcodeJ03556-
dc.identifier.eissn2077-0383-
dc.identifier.pmid34575353-
dc.subject.keywordcoronavirus disease 2019-
dc.subject.keywordmortality-
dc.subject.keywordrespiratory failure-
dc.subject.keywordsoluble interleukin-2 receptor-
dc.contributor.alternativeNameKang, Young Ae-
dc.contributor.affiliatedAuthor강영애-
dc.contributor.affiliatedAuthor김영삼-
dc.contributor.affiliatedAuthor박무석-
dc.contributor.affiliatedAuthor안진영-
dc.contributor.affiliatedAuthor이수환-
dc.contributor.affiliatedAuthor임아영-
dc.contributor.affiliatedAuthor장혜진-
dc.contributor.affiliatedAuthor정경수-
dc.contributor.affiliatedAuthor정지예-
dc.citation.volume10-
dc.citation.number18-
dc.citation.startPage4242-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL MEDICINE, Vol.10(18) : 4242, 2021-09-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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