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Impact of everolimus on survival after liver transplantation for hepatocellular carcinoma
DC Field | Value | Language |
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dc.contributor.author | 김명수 | - |
dc.contributor.author | 김순일 | - |
dc.contributor.author | 김현정 | - |
dc.contributor.author | 이재근 | - |
dc.contributor.author | 주동진 | - |
dc.contributor.author | 최기홍 | - |
dc.contributor.author | 최진섭 | - |
dc.contributor.author | 한대훈 | - |
dc.date.accessioned | 2021-11-19T01:40:10Z | - |
dc.date.available | 2021-11-19T01:40:10Z | - |
dc.date.issued | 2021-10 | - |
dc.identifier.issn | 2287-2728 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/185974 | - |
dc.description.abstract | Background/aims: This study aimed to investigate whether everolimus (EVR) affects long-term survival after liver transplantation (LT) in patients with hepatocellular carcinoma (HCC). Methods: The data from 303 consecutive patients with HCC who had undergone LT from January 2012 to July 2018 were retrospectively reviewed. The patients were divided into two groups: 1) patients treated with EVR in combination with calcineurin inhibitors (CNIs) (EVR group; n=114) and 2) patients treated with CNI-based therapy without EVR (non-EVR group; n=189). Time to recurrence (TTR) and overall survival (OS) after propensity score (PS) matching were compared between the groups, and prognostic factors for TTR and OS were evaluated. Results: The EVR group exhibited more aggressive tumor biology than the non-EVR group, such as a higher number of tumors (P=0.003), a higher prevalence of microscopic vascular invasion (P=0.017) and exceeding Milan criteria (P=0.029). Compared with the PS-matched non-EVR group, the PS-matched EVR group had significantly better TTR (P<0.001) and OS (P<0.001). In multivariable analysis, EVR was identified as an independent prognostic factor for TTR (hazard ratio [HR], 0.248; P=0.001) and OS (HR, 0.145; P<0.001). Conclusion: Combined with CNIs, EVR has the potential to prolong long-term survival in patients undergoing LT for HCC. These findings warrant further investigation in a well-designed prospective study. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Association for the Study of the Liver | - |
dc.relation.isPartOf | CLINICAL AND MOLECULAR HEPATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Impact of everolimus on survival after liver transplantation for hepatocellular carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Incheon Kang | - |
dc.contributor.googleauthor | Jae Geun Lee | - |
dc.contributor.googleauthor | Sung Hoon Choi | - |
dc.contributor.googleauthor | Hyun Jeong Kim | - |
dc.contributor.googleauthor | Dai Hoon Han | - |
dc.contributor.googleauthor | Gi Hong Choi | - |
dc.contributor.googleauthor | Myoung Soo Kim | - |
dc.contributor.googleauthor | Jin Sub Choi | - |
dc.contributor.googleauthor | Soon Il Kim | - |
dc.contributor.googleauthor | Dong Jin Joo | - |
dc.identifier.doi | 10.3350/cmh.2021.0038 | - |
dc.contributor.localId | A00424 | - |
dc.contributor.localId | A00649 | - |
dc.contributor.localId | A06066 | - |
dc.contributor.localId | A03068 | - |
dc.contributor.localId | A03948 | - |
dc.contributor.localId | A04046 | - |
dc.contributor.localId | A04199 | - |
dc.contributor.localId | A04273 | - |
dc.relation.journalcode | J00557 | - |
dc.identifier.eissn | 2287-285X | - |
dc.identifier.pmid | 34293849 | - |
dc.subject.keyword | Hepatocellular carcinoma | - |
dc.subject.keyword | Immunosuppression | - |
dc.subject.keyword | Liver transplantation | - |
dc.subject.keyword | Recurrence | - |
dc.subject.keyword | Survival | - |
dc.contributor.alternativeName | Kim, Myoung Soo | - |
dc.contributor.affiliatedAuthor | 김명수 | - |
dc.contributor.affiliatedAuthor | 김순일 | - |
dc.contributor.affiliatedAuthor | 김현정 | - |
dc.contributor.affiliatedAuthor | 이재근 | - |
dc.contributor.affiliatedAuthor | 주동진 | - |
dc.contributor.affiliatedAuthor | 최기홍 | - |
dc.contributor.affiliatedAuthor | 최진섭 | - |
dc.contributor.affiliatedAuthor | 한대훈 | - |
dc.citation.volume | 27 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 589 | - |
dc.citation.endPage | 602 | - |
dc.identifier.bibliographicCitation | CLINICAL AND MOLECULAR HEPATOLOGY, Vol.27(4) : 589-602, 2021-10 | - |
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