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On-Treatment Blood Pressure and Cardiovascular Outcomes in Adults With Hypertension and Left Ventricular Hypertrophy
DC Field | Value | Language |
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dc.contributor.author | 김현창 | - |
dc.contributor.author | 박성하 | - |
dc.contributor.author | 이혁희 | - |
dc.contributor.author | 이호규 | - |
dc.date.accessioned | 2021-11-19T01:37:31Z | - |
dc.date.available | 2021-11-19T01:37:31Z | - |
dc.date.issued | 2021-10 | - |
dc.identifier.issn | 0735-1097 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/185949 | - |
dc.description.abstract | Background: Benefits of intensive blood pressure lowering on health outcomes have been demonstrated in high-risk patients. However, little is known about such benefits in patients with left ventricular hypertrophy (LVH). Objectives: This study sought to investigate the association of on-treatment blood pressure with cardiovascular disease (CVD) risk in adults with hypertension and LVH. Methods: From a nationwide health examination database, this study identified 95,545 participants aged 40-79 years who were taking antihypertensive medication and had LVH on baseline electrocardiography. Using Cox models, HRs and 95% CIs for CVD events were calculated according to systolic blood pressure (SBP) or diastolic blood pressure (DBP). Results: Over a median follow-up of 11.5 years, 12,035 new CVD events occurred. An SBP of <130 mm Hg and DBP of <80 mm Hg were associated with the lowest risk for CVD events in cubic spline models. When the group with SBP of 120-129 mm Hg was the reference, multivariable-adjusted HRs were 1.31 (95% CI: 1.24-1.38) in the ≥140 mm Hg group, 1.08 (95% CI: 1.02-1.15) in the 130-139 mm Hg group, and 1.03 (95% CI: 0.93-1.15) in the <120 mm Hg group. Likewise, when the group with DBP of 70-79 mm Hg was the reference, multivariable-adjusted HRs were 1.30 (95% CI: 1.24-1.37) in the ≥90 mm Hg group, 1.06 (95% CI: 1.01-1.12) in the 80-89 mm Hg group, and 1.08 (95% CI: 0.96 to 1.20) in the <70 mm Hg group. Conclusions: In adults with hypertension and LVH, the risk for CVD events was the lowest at SBP <130 mm Hg and DBP <80 mm Hg. Further randomized trials are warranted to establish optimal blood pressure-lowering strategies for these patients. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Biomedical | - |
dc.relation.isPartOf | JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | On-Treatment Blood Pressure and Cardiovascular Outcomes in Adults With Hypertension and Left Ventricular Hypertrophy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Preventive Medicine and Public Health (예방의학교실) | - |
dc.contributor.googleauthor | Hyeok-Hee Lee | - |
dc.contributor.googleauthor | Hokyou Lee | - |
dc.contributor.googleauthor | So Mi Jemma Cho | - |
dc.contributor.googleauthor | Dong-Wook Kim | - |
dc.contributor.googleauthor | Sungha Park | - |
dc.contributor.googleauthor | Hyeon Chang Kim | - |
dc.identifier.doi | 10.1016/j.jacc.2021.08.015 | - |
dc.contributor.localId | A01142 | - |
dc.contributor.localId | A01512 | - |
dc.contributor.localId | A06102 | - |
dc.contributor.localId | A05838 | - |
dc.relation.journalcode | J01770 | - |
dc.identifier.eissn | 1558-3597 | - |
dc.identifier.pmid | 34620404 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0735109721059143 | - |
dc.subject.keyword | cardiovascular risk | - |
dc.subject.keyword | hypertension | - |
dc.subject.keyword | left ventricular hypertrophy | - |
dc.subject.keyword | optimal blood pressure | - |
dc.contributor.alternativeName | Kim, Hyeon Chang | - |
dc.contributor.affiliatedAuthor | 김현창 | - |
dc.contributor.affiliatedAuthor | 박성하 | - |
dc.contributor.affiliatedAuthor | 이혁희 | - |
dc.contributor.affiliatedAuthor | 이호규 | - |
dc.citation.volume | 78 | - |
dc.citation.number | 15 | - |
dc.citation.startPage | 1485 | - |
dc.citation.endPage | 1495 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol.78(15) : 1485-1495, 2021-10 | - |
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