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확진된 소아청소년 결핵에서 인터페론감마 분비검사의 진단적 가치
DC Field | Value | Language |
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dc.contributor.author | 강지만 | - |
dc.contributor.author | 안종균 | - |
dc.date.accessioned | 2021-11-19T01:37:04Z | - |
dc.date.available | 2021-11-19T01:37:04Z | - |
dc.date.issued | 2021-04 | - |
dc.identifier.issn | 2384-1079 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/185945 | - |
dc.description.abstract | Purpose: This study aimed to evaluate the diagnostic value of the QuantiFERON-TB Gold In-Tube (QFT-GIT) in children with confirmed tuberculosis (TB). Methods: We retrospectively reviewed the medical records of children aged ≤18 years who underwent both QFT-GIT and Mycobacterium tuberculosis culture between 2006 and 2017. Confirmed TB was defined as the presence of at least one positive specimen for M. tuberculosis on culture or a nucleic acid amplification test. Results: Of the 582 patients included in the analysis, 48 were confirmed to have TB. The sensitivity and specificity of QFT-GIT for the diagnosis of confirmed TB were 85.4% and 95.5%, respectively. Among children with confirmed TB, the proportion in the immunocompromised state was higher in the QFT-GIT negative group than in the QFT-GIT positive group (50.0% vs. 5.7%, P=0.010). The median age at sampling was lower in the QFT-GIT indeterminate group than in the QFT-GIT positive group (7 years vs. 17 years, P=0.008), and the proportion of immunosuppression was higher in the QFT-GIT indeterminate group than in the QFT-GIT positive group (42.9% vs. 5.7%, P=0.017). The interferon gamma response to mitogen control was significantly higher in the 10-18 years group than in the 0-9 years group (P<0.001), and was significantly higher in the immunocompetent group than in the immunocompromised group (P=0.001). Conclusion: The QFT-GIT results should be interpreted carefully in immunocompromised or younger children suspected of having TB. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | Korean Society of Pediatric Infectious Diseases | - |
dc.relation.isPartOf | Pediatric Infection & Vaccine | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 확진된 소아청소년 결핵에서 인터페론감마 분비검사의 진단적 가치 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학교실) | - |
dc.contributor.googleauthor | 김규호 | - |
dc.contributor.googleauthor | 강지만 | - |
dc.contributor.googleauthor | 안종균 | - |
dc.identifier.doi | 10.14776/piv.2021.28.e5 | - |
dc.contributor.localId | A05720 | - |
dc.contributor.localId | A02261 | - |
dc.relation.journalcode | J02486 | - |
dc.identifier.eissn | 2384-1087 | - |
dc.subject.keyword | Tuberculosis | - |
dc.subject.keyword | Interferon-gamma release assay | - |
dc.subject.keyword | Children | - |
dc.contributor.alternativeName | Kang, Ji-Man | - |
dc.contributor.affiliatedAuthor | 강지만 | - |
dc.contributor.affiliatedAuthor | 안종균 | - |
dc.citation.volume | 28 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 31 | - |
dc.citation.endPage | 41 | - |
dc.identifier.bibliographicCitation | Pediatric Infection & Vaccine, Vol.28(1) : 31-41, 2021-04 | - |
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