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Characterization of HIV-1 recombinant and subtype B near full-length genome among men who have sex with men in South Korea
DC Field | Value | Language |
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dc.contributor.author | 최준용 | - |
dc.date.accessioned | 2021-10-21T00:20:08Z | - |
dc.date.available | 2021-10-21T00:20:08Z | - |
dc.date.issued | 2021-02 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/185482 | - |
dc.description.abstract | In Korea, subtype B is the predominant variant of HIV-1, but full genome sequencing and analysis of its viral variants are lacking. We performed near full-length genome (NFLG) sequencing and phylogenetic and recombination analyses of fifty plasma samples from HIV-positive men who have sex with men (MSM) from a Korea HIV/AIDS cohort study. Viral genomes were amplified and the near-full-length sequences were determined using next-generation sequencing (NGS) and Sanger sequencing. We focused on the HIV-1 subtype classification and identification of HIV recombinants. Twelve HIV-1 NFLGs were determined: ten were subtyped as pure HIV-1 subtype B and two recombinant strains as a common subtype CRF07_BC, and a novel subtype CRF43_02G recombined with CRF02_AG again, or a new CRF02_AG and subtype G recombinant. For the ten NFLGs determined by NGS, "the novel recombinant emerged at approximately 2003 and the other nine subtype B about 2004 or 2005". This is the first report analyzing HIV-1 NFLG, including recombinants and clinical characteristics, by subtype among MSM in Korea. Our results provide novel insights for understanding the recombinants in the HIV-1 epidemic in Korea. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Characterization of HIV-1 recombinant and subtype B near full-length genome among men who have sex with men in South Korea | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Sangmi Ryou | - |
dc.contributor.googleauthor | Myeongsu Yoo | - |
dc.contributor.googleauthor | Kisoon Kim | - |
dc.contributor.googleauthor | Sangsoo Kim | - |
dc.contributor.googleauthor | Sang Il Kim | - |
dc.contributor.googleauthor | Youn Jeong Kim | - |
dc.contributor.googleauthor | Dae Won Park | - |
dc.contributor.googleauthor | Jun Yong Choi | - |
dc.contributor.googleauthor | Hyo Youl Kim | - |
dc.contributor.googleauthor | Jung Ho Kim | - |
dc.contributor.googleauthor | Joon Young Song | - |
dc.contributor.googleauthor | Shin-Woo Kim | - |
dc.contributor.googleauthor | Hyun-Ha Chang | - |
dc.contributor.googleauthor | Bo Youl Choi | - |
dc.contributor.googleauthor | Mee-Kyung Kee | - |
dc.identifier.doi | 10.1038/s41598-021-82872-3 | - |
dc.contributor.localId | A04191 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 33602986 | - |
dc.contributor.alternativeName | Choi, Jun Yong | - |
dc.contributor.affiliatedAuthor | 최준용 | - |
dc.citation.volume | 11 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 4122 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.11(1) : 4122, 2021-02 | - |
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