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Dynamics and Predictors of Mortality Due to Candidemia Caused by Different Candida Species: Comparison of Intensive Care Unit-Associated Candidemia (ICUAC) and Non-ICUAC
DC Field | Value | Language |
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dc.contributor.author | 정석훈 | - |
dc.date.accessioned | 2021-10-21T00:19:58Z | - |
dc.date.available | 2021-10-21T00:19:58Z | - |
dc.date.issued | 2021-08 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/185480 | - |
dc.description.abstract | We investigated mortality and predictors of mortality due to intensive care unit-associated candidemia (ICUAC) versus non-ICUAC by Candida species. This study included all candidemia cases in 11 hospitals from 2017 to 2018 in South Korea. The all-cause mortality rates in all 370 patients with ICUAC were approximately twofold higher than those in all 437 patients with non-ICUAC at 7 days (2.3-fold, 31.1%/13.3%), 30 days (1.9-fold, 49.5%/25.4%), and 90 days (1.9-fold, 57.8%/30.9%). Significant species-specific associations with 7- and 30-day ICUAC-associated mortality were not observed. Multivariate analysis revealed that ICU admission was an independent predictor of Candida glabrata (OR, 2.07-2.48) and Candida parapsilosis-associated mortality (OR, 6.06-11.54). Fluconazole resistance was a predictor of C. glabrata-associated mortality (OR, 2.80-5.14). Lack (less than 3 days) of antifungal therapy was the strongest predictor of 7-day mortality due to ICUAC caused by Candida albicans (OR, 18.33), Candida tropicalis (OR, 10.52), and C. glabrata (OR, 21.30) compared with 30- and 90-day mortality (OR, 2.72-6.90). C. glabrata ICUAC had a stronger association with lack of antifungal therapy (55.2%) than ICUAC caused by other species (30.6-36.7%, all p < 0.05). Most predictors of mortality associated with ICUAC were distinct from those associated with non-ICUAC and were mediated by Candida species. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | JOURNAL OF FUNGI | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Dynamics and Predictors of Mortality Due to Candidemia Caused by Different Candida Species: Comparison of Intensive Care Unit-Associated Candidemia (ICUAC) and Non-ICUAC | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | Yong Jun Kwon | - |
dc.contributor.googleauthor | Eun Jeong Won | - |
dc.contributor.googleauthor | Seok Hoon Jeong | - |
dc.contributor.googleauthor | Kyeong Seob Shin | - |
dc.contributor.googleauthor | Jeong Hwan Shin | - |
dc.contributor.googleauthor | Young Ree Kim | - |
dc.contributor.googleauthor | Hyun Soo Kim | - |
dc.contributor.googleauthor | Young Ah Kim | - |
dc.contributor.googleauthor | Young Uh | - |
dc.contributor.googleauthor | Taek Soo Kim | - |
dc.contributor.googleauthor | Jae Hyeon Park | - |
dc.contributor.googleauthor | Jaehyeon Lee | - |
dc.contributor.googleauthor | Min Ji Choi | - |
dc.contributor.googleauthor | Seung A Byun | - |
dc.contributor.googleauthor | Soo Hyun Kim | - |
dc.contributor.googleauthor | Jong Hee Shin | - |
dc.identifier.doi | 10.3390/jof7080597 | - |
dc.contributor.localId | A03619 | - |
dc.relation.journalcode | J04005 | - |
dc.identifier.eissn | 2309-608X | - |
dc.identifier.pmid | 34436136 | - |
dc.subject.keyword | Candida species | - |
dc.subject.keyword | ICU | - |
dc.subject.keyword | candidemia | - |
dc.subject.keyword | lack of antifungal therapy | - |
dc.subject.keyword | mortality | - |
dc.contributor.alternativeName | Jeong, Seok Hoon | - |
dc.contributor.affiliatedAuthor | 정석훈 | - |
dc.citation.volume | 7 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 597 | - |
dc.identifier.bibliographicCitation | JOURNAL OF FUNGI, Vol.7(8) : 597, 2021-08 | - |
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