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Effect of Psychosocial Distress on the Rate of Kidney Function Decline

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dc.contributor.author강신욱-
dc.contributor.author박정탁-
dc.contributor.author유태현-
dc.contributor.author주영수-
dc.contributor.author지종현-
dc.contributor.author한승혁-
dc.date.accessioned2021-10-21T00:17:33Z-
dc.date.available2021-10-21T00:17:33Z-
dc.date.issued2021-10-
dc.identifier.issn0884-8734-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/185462-
dc.description.abstractBackgrounds: Chronic kidney disease is a growing global health problem. Psychosocial stress has been found to induce changes in biological processes and behavioral patterns that increase risks of cardiovascular and metabolic diseases. However, the association between psychosocial stress and kidney function is not well understood. Objective: To evaluate the association between psychosocial stress and kidney function decline. Design: In this prospective cohort study, psychosocial distress was assessed using the psychosocial well-being index short-form (PWI-SF). Participants: Data of a total of 7246 participants were retrieved from a community-based cohort (Korean Genome and Epidemiology Study). Main measures: The rate of estimated glomerular filtration rate (eGFR) decline was calculated for each individual. Rapid eGFR decline was defined as a decrease of ≥ 3 mL/min/1.73 m2 per year. The presence of kidney disease was defined as eGFR < 60 mL/min/1.73 m2 at baseline or proteinuria of higher than trace levels from two consecutive urine test results. Key results: A total of 7246 participants were analyzed. The mean eGFR was 92.1 ± 14.0 mL/min/1.73 m2. Rapid eGFR decline was observed in 941 (13.0%) participants during a median follow-up of 11.7 years. When the participants were categorized into tertiles according to PWI-SF score, rapid eGFR decline was more prevalent in the group with the highest PWI-SF score (15.8%) than in the group with the lowest score (12.2%). Multivariate logistic regression analysis revealed that the risk of rapid eGFR decline was significantly increased in the tertile group with the highest PWI-SF score compared to the lowest group (odds ratio, 1.35; 95% confidence interval, 1.15-1.59). This association was maintained even after adjusting for confounding variables and excluding participants with kidney disease. Conclusions: Higher levels of psychosocial distress were closely associated with an increased risk of rapid kidney function decline.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherHanley & Belfus-
dc.relation.isPartOfJOURNAL OF GENERAL INTERNAL MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEffect of Psychosocial Distress on the Rate of Kidney Function Decline-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJae Young Kim-
dc.contributor.googleauthorYoung Su Joo-
dc.contributor.googleauthorJong Hyun Jhee-
dc.contributor.googleauthorSeung Hyeok Han-
dc.contributor.googleauthorTae-Hyun Yoo-
dc.contributor.googleauthorShin-Wook Kang-
dc.contributor.googleauthorJung Tak Park-
dc.identifier.doi10.1007/s11606-020-06573-9-
dc.contributor.localIdA00053-
dc.contributor.localIdA01654-
dc.contributor.localIdA02526-
dc.contributor.localIdA03956-
dc.contributor.localIdA03970-
dc.contributor.localIdA04304-
dc.relation.journalcodeJ04117-
dc.identifier.eissn1525-1497-
dc.identifier.pmid33469756-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs11606-020-06573-9-
dc.subject.keywordeGFR-
dc.subject.keywordkidney disease-
dc.subject.keywordpsychosocial distress-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.affiliatedAuthor강신욱-
dc.contributor.affiliatedAuthor박정탁-
dc.contributor.affiliatedAuthor유태현-
dc.contributor.affiliatedAuthor주영수-
dc.contributor.affiliatedAuthor지종현-
dc.contributor.affiliatedAuthor한승혁-
dc.citation.volume36-
dc.citation.number10-
dc.citation.startPage2966-
dc.citation.endPage2974-
dc.identifier.bibliographicCitationJOURNAL OF GENERAL INTERNAL MEDICINE, Vol.36(10) : 2966-2974, 2021-10-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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