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Molecular Characterization of the First Emerged NDM-1-Producing Pseudomonas aeruginosa Isolates in South Korea
DC Field | Value | Language |
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dc.contributor.author | 정석훈 | - |
dc.date.accessioned | 2021-10-21T00:17:20Z | - |
dc.date.available | 2021-10-21T00:17:20Z | - |
dc.date.issued | 2021-08 | - |
dc.identifier.issn | 1076-6294 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/185459 | - |
dc.description.abstract | Carbapenemase-producing Pseudomonas aeruginosa (CPPA) is a threat to public health. This study aimed to describe the first emergence and molecular characterization of NDM-1-producing P. aeruginosa in South Korea. A total of 183 carbapenem-resistant P. aeruginosa (CRPA) isolates were recovered from patients at a university hospital in Seoul, South Korea. The antimicrobial resistance genes and their genetic environments were determined through molecular sequencing. Antimicrobial susceptibility testing was performed using the VITEK 2 system and broth microdilution method. Genetic relatedness was assessed using multilocus sequence typing and pulsed-field gel electrophoresis. Whole genome sequencing (WGS) was carried out to analyze the entire genome of a CPPA isolated from the index patient; the first identified infected patient. All 16 CPPA isolates from the 183 CRPA carried the blaNDM-1 gene and exhibited a high level of resistance to β-lactams, aminoglycosides, and ciprofloxacin. Fifteen of the 16 isolates were recovered from urine samples. They were attributed to ST773 and showed high clonal similarity (>86%). Post-WGS analysis revealed that the blaNDM-1 gene and the 16S rRNA methyltransferase gene rmtB4 were located in the integrative and conjugative element (ICE) on the chromosome. This ICE6660-like region was very similar to the ICE6660 region carrying the blaNDM-1 gene and the 16S rRNA methyltransferase gene rmtD3 in a previously described P. aeruginosa strain. This study described the first emergence and clonal spread of the NDM-1-producing P. aeruginosa ST773 isolates possessing rmtB4, at a university hospital in South Korea, suggesting that continuous surveillance is necessary to prevent infection and transmission of these CRPAs, which can endanger public health. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Mary Ann Liebert | - |
dc.relation.isPartOf | MICROBIAL DRUG RESISTANCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Molecular Characterization of the First Emerged NDM-1-Producing Pseudomonas aeruginosa Isolates in South Korea | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | Jun Sung Hong | - |
dc.contributor.googleauthor | Wonkeun Song | - |
dc.contributor.googleauthor | Min-Jeong Park | - |
dc.contributor.googleauthor | Seri Jeong | - |
dc.contributor.googleauthor | Nuri Lee | - |
dc.contributor.googleauthor | Seok Hoon Jeong | - |
dc.identifier.doi | 10.1089/mdr.2020.0374 | - |
dc.contributor.localId | A03619 | - |
dc.relation.journalcode | J02229 | - |
dc.identifier.eissn | 1931-8448 | - |
dc.identifier.pmid | 33332204 | - |
dc.identifier.url | https://www.liebertpub.com/doi/10.1089/mdr.2020.0374 | - |
dc.subject.keyword | NDM-1 | - |
dc.subject.keyword | Pseudomonas aeruginosa | - |
dc.subject.keyword | ST773 | - |
dc.subject.keyword | integrative and conjugative element | - |
dc.subject.keyword | rmtB4 | - |
dc.contributor.alternativeName | Jeong, Seok Hoon | - |
dc.contributor.affiliatedAuthor | 정석훈 | - |
dc.citation.volume | 27 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1063 | - |
dc.citation.endPage | 1070 | - |
dc.identifier.bibliographicCitation | MICROBIAL DRUG RESISTANCE, Vol.27(8) : 1063-1070, 2021-08 | - |
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