Cited 5 times in
Mixed- versus predilution hemodiafiltration effects on convection volume and small and middle molecule clearance in hemodialysis patients: a prospective randomized controlled trial
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강신욱 | - |
dc.contributor.author | 박정탁 | - |
dc.contributor.author | 유태현 | - |
dc.contributor.author | 조원지 | - |
dc.contributor.author | 한승혁 | - |
dc.date.accessioned | 2021-10-21T00:15:57Z | - |
dc.date.available | 2021-10-21T00:15:57Z | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 2211-9132 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/185447 | - |
dc.description.abstract | Background: The use of newly developed mixed-dilution hemodiafiltration (HDF) can supplement the weaknesses of pre- and postdilution HDF. However, it is unclear whether mixed-HDF performs well compared to predilution HDF. Methods: We conducted a prospective, open-labeled, randomized controlled trial from two hemodialysis centers in Korea. Between January 2017 and September 2019, 60 patients who underwent chronic hemodialysis were randomly assigned at a 1:1 ratio to receive either predilution HDF (n = 30) or mixed-HDF (n = 30) for 6 months. We compared convection volume, changes in small- and medium-sized molecule clearance, high-sensitive C-reactive protein (hs-CRP) level, and dialysis-related parameters between the two dialysis modalities. Results: A mean effective convection volume of 41.0 ± 10.3 L/session in the predilution HDF group and 51.5 ± 9.0 L/session in the mixed-HDF group was obtained by averaging values of three time-points. The difference in effective convection volume between the groups was 10.5 ± 1.3 L/session. This met the preset noninferiority criteria, suggesting that mixed-HDF was noninferior to predilution HDF. Moreover, the β2-microglobulin reduction rate was greater in the mixed-HDF group than in the predilution HDF group, while mixed-HDF provided greater transmembrane pressure. There were no significant between-group differences in Kt/V urea levels, changes in predialysis hs-CRP levels, proportions of overhydration, or blood pressure values. Symptomatic intradialytic hypotension episodes and other adverse events occurred similarly in the two groups. Conclusion: Use of mixed-HDF was comparable to predilution HDF in terms of delivered convection volume and clinical parameters. Moreover, mixed-HDF provided better β2-microglobulin clearance than predilution HDF. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Elsevier Korea | - |
dc.relation.isPartOf | KIDNEY RESEARCH AND CLINICAL PRACTICE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Mixed- versus predilution hemodiafiltration effects on convection volume and small and middle molecule clearance in hemodialysis patients: a prospective randomized controlled trial | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Kyoung Sook Park | - |
dc.contributor.googleauthor | Ea Wha Kang | - |
dc.contributor.googleauthor | Tae Ik Chang | - |
dc.contributor.googleauthor | Wonji Jo | - |
dc.contributor.googleauthor | Jung Tak Park | - |
dc.contributor.googleauthor | Tae-Hyun Yoo | - |
dc.contributor.googleauthor | Shin-Wook Kang | - |
dc.contributor.googleauthor | Seung Hyeok Han | - |
dc.identifier.doi | 10.23876/j.krcp.21.044 | - |
dc.contributor.localId | A00053 | - |
dc.contributor.localId | A01654 | - |
dc.contributor.localId | A02526 | - |
dc.contributor.localId | A05982 | - |
dc.contributor.localId | A04304 | - |
dc.relation.journalcode | J01942 | - |
dc.identifier.eissn | 2211-9140 | - |
dc.identifier.pmid | 34370930 | - |
dc.subject.keyword | Convection volume | - |
dc.subject.keyword | Hemodiafiltration | - |
dc.subject.keyword | Mixed online hemodiafiltration | - |
dc.subject.keyword | Randomized controlled trial | - |
dc.contributor.alternativeName | Kang, Shin Wook | - |
dc.contributor.affiliatedAuthor | 강신욱 | - |
dc.contributor.affiliatedAuthor | 박정탁 | - |
dc.contributor.affiliatedAuthor | 유태현 | - |
dc.contributor.affiliatedAuthor | 조원지 | - |
dc.contributor.affiliatedAuthor | 한승혁 | - |
dc.citation.volume | 40 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 445 | - |
dc.citation.endPage | 456 | - |
dc.identifier.bibliographicCitation | KIDNEY RESEARCH AND CLINICAL PRACTICE, Vol.40(3) : 445-456, 2021-09 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.