Cited 2 times in
Ethnic similarities in genetic polymorphisms associated with atrial fibrillation: Far East Asian vs European populations
DC Field | Value | Language |
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dc.contributor.author | 김태훈 | - |
dc.contributor.author | 박희남 | - |
dc.contributor.author | 심재민 | - |
dc.contributor.author | 엄재선 | - |
dc.contributor.author | 유희태 | - |
dc.contributor.author | 이문형 | - |
dc.contributor.author | 정보영 | - |
dc.contributor.author | 지선하 | - |
dc.date.accessioned | 2021-10-21T00:14:06Z | - |
dc.date.available | 2021-10-21T00:14:06Z | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 0014-2972 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/185434 | - |
dc.description.abstract | Background: In European ancestry, 111 genetic loci were identified as associated with atrial fibrillation (AF). We explored the reproducibility of those single nucleotide polymorphisms (SNPs) in a genome-wide association study (GWAS) meta-analysis of Far East Asian populations. Methods: We performed a meta-analysis of the Korean AF network and Japanese AF data sets (9118 cases and 33 467 controls) by an inverse-variance fixed-effects model. We compared the results with 111 previously reported SNPs proven in Europeans after excluding 36 missing loci and a locus with a minor allelic frequency (MAF) < 0.01 in the European population. Results: Among remaining 74 loci, 29 loci were replicated at a P < .05, and 17 of those loci were newly found in the Far East Asian population: 3 loci with a P < 5×10-8 (METTL11B at 1q24, KCNN2 at 5q22 and LRMDA at 10q22), 4 loci at the threshold of the Bonferroni correction of P = 4.5 × 10-4 ~ 5×10-8 (KIF3C at 2p23, REEP3, NRBF2 at 10q21, SIRT1, MYPN at 10q21 and CFL2 at 14q13) and 10 SNPs with a P = .05 ~ 4.5 × 10-4 . Among 18 AF loci with a MAF< 0.01 in the Far East Asian populations, 2 loci (GATA4 at 8q23 and SGCG at 13q12) were replicated after a fine mapping. Twenty-seven AF loci, including a locus, which had a sufficient sample size to get a power of over 80% (with a type 1 error α = 4.5 × 10-4 ), were not replicated in the Far East Asian populations. Conclusions: We newly replicated 19 AF-associated genetic loci in the European descent among the Far East Asian populations. It highlights the extensive sharing of AF genetic risks across Far East Asian populations. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Ethnic similarities in genetic polymorphisms associated with atrial fibrillation: Far East Asian vs European populations | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | Myunghee Hong | - |
dc.contributor.googleauthor | Yusuke Ebana | - |
dc.contributor.googleauthor | Jaemin Shim | - |
dc.contributor.googleauthor | Eue-Keun Choi | - |
dc.contributor.googleauthor | Hong Euy Lim | - |
dc.contributor.googleauthor | Inseok Hwang | - |
dc.contributor.googleauthor | Hee Tae Yu | - |
dc.contributor.googleauthor | Tae-Hoon Kim | - |
dc.contributor.googleauthor | Jae-Sun Uhm | - |
dc.contributor.googleauthor | Boyoung Joung | - |
dc.contributor.googleauthor | Seil Oh | - |
dc.contributor.googleauthor | Moon-Hyoung Lee | - |
dc.contributor.googleauthor | Young-Hoon Kim | - |
dc.contributor.googleauthor | Sun Ha Jee | - |
dc.contributor.googleauthor | Hui-Nam Pak | - |
dc.identifier.doi | 10.1111/eci.13584 | - |
dc.contributor.localId | A01086 | - |
dc.contributor.localId | A01776 | - |
dc.contributor.localId | A02206 | - |
dc.contributor.localId | A02337 | - |
dc.contributor.localId | A02535 | - |
dc.contributor.localId | A02766 | - |
dc.contributor.localId | A03609 | - |
dc.contributor.localId | A03965 | - |
dc.relation.journalcode | J00814 | - |
dc.identifier.eissn | 1365-2362 | - |
dc.identifier.pmid | 33990960 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/eci.13584 | - |
dc.subject.keyword | Asian | - |
dc.subject.keyword | atrial fibrillation | - |
dc.subject.keyword | genetics | - |
dc.subject.keyword | genome-wide association study | - |
dc.subject.keyword | meta-analysis | - |
dc.contributor.alternativeName | Kim, Tae Hoon | - |
dc.contributor.affiliatedAuthor | 김태훈 | - |
dc.contributor.affiliatedAuthor | 박희남 | - |
dc.contributor.affiliatedAuthor | 심재민 | - |
dc.contributor.affiliatedAuthor | 엄재선 | - |
dc.contributor.affiliatedAuthor | 유희태 | - |
dc.contributor.affiliatedAuthor | 이문형 | - |
dc.contributor.affiliatedAuthor | 정보영 | - |
dc.contributor.affiliatedAuthor | 지선하 | - |
dc.citation.volume | 51 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | e13584 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Vol.51(9) : e13584, 2021-09 | - |
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