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Clinical significance of large unstained cell count in estimating the current activity of antineutrophil cytoplasmic antibody-associated vasculitis

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dc.contributor.author박용범-
dc.contributor.author송정식-
dc.contributor.author안성수-
dc.contributor.author이상원-
dc.contributor.author이은주-
dc.contributor.author표정윤-
dc.date.accessioned2021-10-21T00:07:37Z-
dc.date.available2021-10-21T00:07:37Z-
dc.date.issued2021-10-
dc.identifier.issn1368-5031-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/185388-
dc.description.abstractBackground: We investigated whether large unstained cell (LUC) count could estimate the current high activity according to Birmingham vasculitis activity score (BVAS) in patients with antineutrophil cytoplasmic antibody (ANCA) positive ANCA-associated vasculitis (AAV). Methods: We retrospectively reviewed the medical records of 176 immunosuppressive drug-naïve patients with ANCA positive AAV. Clinical and laboratory data at diagnosis, including LUC count, were collected. High BVAS was defined as the highest tertile of BVAS (BVAS ≥ 15) in this study. Results: The median age was 61.0 years, and 64.8% were female. The median LUC count was 60.0 mm3 , and LUC was detected in 106 patients. LUC count was significantly correlated with BVAS, age, white blood cell count, haemoglobin, platelet count, serum albumin, erythrocyte sedimentation rate and C-reactive protein. Overall, the median BVAS in AAV patients with LUC positivity was significantly higher than that in those without (14.0 vs 10.0). When the cut-off of LUC count for the current high BVAS was set as BVAS ≥ 15 mm3 , AAV patients with LUC count ≥ 15 mm3 had a significantly higher risk for the current high BVAS than those with LUC count < 15 mm3 (relative risk 2.596). However, in the multivariable linear and logistic regression analyses, LUC did not seem to estimate the current BVAS independently among clinical and laboratory variables. Conclusion: LUC count was significantly correlated with the current BVAS and LUC count ≥ 15 mm3 could estimate the current high BVAS in patients with ANCA positive AAV.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF CLINICAL PRACTICE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis* / drug therapy-
dc.subject.MESHAntibodies, Antineutrophil Cytoplasmic*-
dc.subject.MESHBlood Cell Count-
dc.subject.MESHBlood Sedimentation-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRetrospective Studies-
dc.titleClinical significance of large unstained cell count in estimating the current activity of antineutrophil cytoplasmic antibody-associated vasculitis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorLucy Eunju Lee-
dc.contributor.googleauthorJung Yoon Pyo-
dc.contributor.googleauthorSung Soo Ahn-
dc.contributor.googleauthorJason Jungsik Song-
dc.contributor.googleauthorYong-Beom Park-
dc.contributor.googleauthorSang-Won Lee-
dc.identifier.doi10.1111/ijcp.14512-
dc.contributor.localIdA01579-
dc.contributor.localIdA02057-
dc.contributor.localIdA02233-
dc.contributor.localIdA02824-
dc.contributor.localIdA05935-
dc.contributor.localIdA04244-
dc.relation.journalcodeJ01099-
dc.identifier.eissn1742-1241-
dc.identifier.pmid34118131-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/10.1111/ijcp.14512-
dc.contributor.alternativeNamePark, Yong Beom-
dc.contributor.affiliatedAuthor박용범-
dc.contributor.affiliatedAuthor송정식-
dc.contributor.affiliatedAuthor안성수-
dc.contributor.affiliatedAuthor이상원-
dc.contributor.affiliatedAuthor이은주-
dc.contributor.affiliatedAuthor표정윤-
dc.citation.volume75-
dc.citation.number10-
dc.citation.startPagee14512-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF CLINICAL PRACTICE, Vol.75(10) : e14512, 2021-10-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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